Lessons from randomized phase III studies with active cancer immunotherapies–outcomes from the 2006 meeting of the Cancer Vaccine Consortium (CVC)
LH Finke, K Wentworth, B Blumenstein, NS Rudolph… - Vaccine, 2007 - Elsevier
… the current state of late-stage development of active cancer immunotherapies. Based on the
composite experience from these recent phase III studies, we suggest strategies to aid future …
composite experience from these recent phase III studies, we suggest strategies to aid future …
Adjuvant active specific immunotherapy for human colorectal cancer: 6.5-year median follow-up of a phase III prospectively randomized trial.
HC Hoover Jr, JS Brandhorst, LC Peters… - Journal of Clinical …, 1993 - ascopubs.org
… for colon and rectal cancer patients. In the 1985 analysis, all patients were … of immunotherapy
is limited to patients with colon cancer. There is no perceived benefit in rectal cancer …
is limited to patients with colon cancer. There is no perceived benefit in rectal cancer …
Adjuvant MAGE-A3 immunotherapy in resected non–small-cell lung cancer: phase II randomized study results
J Vansteenkiste, M Zielinski, A Linder… - Journal of Clinical …, 2013 - ascopubs.org
… a randomized, double-blind, placebo-controlled phase II trial of adjuvant MAGE-A3
immunotherapeutic (2:1 randomization … resected MAGE-A3–positive TNM stage 18 IB or II NSCLC. …
immunotherapeutic (2:1 randomization … resected MAGE-A3–positive TNM stage 18 IB or II NSCLC. …
Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial
JB Vermorken, AME Claessen, H Van Tinteren, HE Gall… - The Lancet, 1999 - thelancet.com
… Colon cancer is … immunotherapy (ASI) with an autologous tumour cell-BCG vaccine with
surgical resection was more beneficial than resection alone in stage II and III colon cancer. …
surgical resection was more beneficial than resection alone in stage II and III colon cancer. …
Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial
… In a phase I study that included patients with mRCC, … the results of a randomized phase II
trial that evaluated three doses of … immunotherapy in mRCC. There are a number of ongoing …
trial that evaluated three doses of … immunotherapy in mRCC. There are a number of ongoing …
Improved endpoints for cancer immunotherapy trials
A Hoos, AMM Eggermont, S Janetzki… - … the National Cancer …, 2010 - academic.oup.com
… immunotherapeutic agents may differ regarding presence and timing of delayed separation,
randomized phase II trials may improve the ability to plan for definitive phase III trials. …
randomized phase II trials may improve the ability to plan for definitive phase III trials. …
Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
PW Kantoff, TJ Schuetz, BA Blumenstein… - Journal of Clinical …, 2010 - ascopubs.org
… to evaluate PROSTVAC-VF in a randomized, controlled, and blinded … randomized phase
II trial reported here was originated under industrial sponsorship with a collaborative research …
II trial reported here was originated under industrial sponsorship with a collaborative research …
Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III …
RHI Andtbacka, F Collichio, KJ Harrington… - … for immunotherapy of …, 2019 - Springer
… Talimogene laherparepvec is an oncolytic immunotherapy approved in the US, Europe, …
of OPTiM, a randomized open-label phase III trial in patients with unresectable stage IIIB–…
of OPTiM, a randomized open-label phase III trial in patients with unresectable stage IIIB–…
Randomized phase II/III clinical trial of elpamotide for patients with advanced pancreatic cancer: PEGASUS‐PC Study
H Yamaue, T Tsunoda, M Tani, M Miyazawa… - Cancer …, 2015 - Wiley Online Library
… Immunotherapy is a growing field of treatment for cancer, and over 100 clinical … results of
the phase I trial, we have carried out a randomized phase II/III clinical trial using elpamotide for …
the phase I trial, we have carried out a randomized phase II/III clinical trial using elpamotide for …
Immunotherapy in patients with metastatic castration-resistant prostate cancer: a meta-analysis of data from 7 phase III studies and 3 phase II studies
A Zhang, D Tong - Experimental Hematology & Oncology, 2022 - Springer
… safety of immunotherapy in large-scale samples. We performed a meta-analysis of 7 phase
III randomized trials and 3 phase II trials comparing immunotherapy to placebo in mCRPC. …
III randomized trials and 3 phase II trials comparing immunotherapy to placebo in mCRPC. …
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