Revisiting epithelial‐mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness

TT Liao, MH Yang - Molecular oncology, 2017 - Wiley Online Library
… of metastasis. In summary, dynamic changes or plasticity between the epithelial and the …
tumors are needed for the establishment of a comprehensive profile of cancer metastasis. …

Epithelial plasticity: a common theme in embryonic and cancer cells

MA Nieto - Science, 2013 - science.org
epithelial plasticity during metastatic colonization and the need for cancer cells to revert to
the epithelial phenotype through a MET (16, 60), rather than preventing metastasis, inhibiting …

Epithelial plasticity, cancer stem cells and bone metastasis formation

G van der Pluijm - Bone, 2011 - Elsevier
… Recent studies have demonstrated that EMT may render cancer cells … of epithelial plasticity
in the multistep processes of bone metastasis, the issue of minimal residual disease, cancer

Controversies around epithelial–mesenchymal plasticity in cancer metastasis

ED Williams, D Gao, A Redfern… - Nature Reviews Cancer, 2019 - nature.com
… is collectively encompassed by the term ‘epithelial–mesenchymal plasticity’ (EMP), which …
over ‘epithelial plasticity’ 14,15 , a more general term indicating flexibility in the epithelial state. …

Epithelial-mesenchymal plasticity in cancer progression and metastasis

W Lu, Y Kang - Developmental cell, 2019 - cell.com
… the regulatory mechanisms and pathological roles of epithelial-mesenchymal plasticity, with
a focus on recent insights into the complexity and dynamics of this phenomenon in cancer. …

Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis

J Gotzmann, M Mikula, A Eger… - … Research/Reviews in …, 2004 - Elsevier
epithelial plasticity. Table 1 integrates currently known in vitro models of epithelial cell plasticity
Epithelial cells derived from the breast, the kidney and the skin have been predominantly …

Cellular plasticity in cancer

S Yuan, RJ Norgard, BZ Stanger - Cancer discovery, 2019 - AACR
… , including tumor initiation and metastasis, immune evasion, and chemoresistance.
Consequently, elucidating the mechanisms by which cancer cells exploit plasticity to cope with …

Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling

M Jechlinger, S Grünert, H Beug - Journal of mammary gland biology and …, 2002 - Springer
… specify distinct types of epithelial plasticity correlated with steps in cancer progression and
metastasis. The existence of several distinct epithelial plasticity phenotypes is also strongly …

EMT, cell plasticity and metastasis

CL Chaffer, BP San Juan, E Lim… - Cancer and Metastasis …, 2016 - Springer
… enhances the metastatic phenotype by … cancer cell plasticity during cancer progression,
with a focus on their role in promoting successful completion of the later stages of the metastatic

The epigenetics of epithelial-mesenchymal plasticity in cancer

WL Tam, RA Weinberg - Nature medicine, 2013 - nature.com
epithelial phenotype is a default state of epithelial cells. Contextual signals promote the
epigenetic repression of key epithelial … , which help define the plasticity of epithelial cells and the …