A comprehensive review of cancer MicroRNA therapeutic delivery strategies

A Forterre, H Komuro, S Aminova, M Harada - Cancers, 2020 - mdpi.com
… in therapeutic miRNA usage are the stability and the deliverystrategies for the development
of therapeutic miRNA delivery systems that includes virus-based delivery, non-viral delivery (…

MicroRNAs and their big therapeutic impacts: delivery strategies for cancer intervention

C Holjencin, A Jakymiw - Cells, 2022 - mdpi.com
… the clinic for cancer treatment that … miRNA delivery platforms for cancer intervention, along
with a discussion of the emergence of peptides as potential carriers for miRNA-based cancer

In vivo delivery of miRNAs for cancer therapy: challenges and strategies

Y Chen, DY Gao, L Huang - Advanced drug delivery reviews, 2015 - Elsevier
… This review discusses the key challenges to the development of the carriers for miRNA-based
therapy and explores current strategies to systemically deliver miRNAs to cancer without …

Nanocarriers for microRNA delivery in cancer medicine

I Fernandez-Piñeiro, I Badiola, A Sanchez - Biotechnology advances, 2017 - Elsevier
… the application of nanomedicine to cancer therapy. This review covers the different miRNA
therapeutic strategies and delivery challenges for its application in cancer medicine. Current …

Therapeutic microRNA delivery strategies with special emphasis on cancer therapy and tumorigenesis: current trends and future challenges

C Chakraborty, ZH Wen… - Current drug …, 2016 - ingentaconnect.com
microRNA delivery strategies and also briefly discuss the different miRNA delivery systems
… -based (LNA-based) compounds delivery without any delivery-mediated agent. Finally, we …

Targeting microRNAs in cancer: rationale, strategies and challenges

R Garzon, G Marcucci, CM Croce - Nature reviews Drug discovery, 2010 - nature.com
… There are two main strategies to target miRNA expression in cancer. Direct strategies involve
… of an oncogenic miRNA or to substitute for the loss of expression of a tumour suppressor …

Progress in microRNA delivery

Y Zhang, Z Wang, RA Gemeinhart - Journal of controlled release, 2013 - Elsevier
strategies of nonviral miRNA delivery systems and provide a perspective on the future of
miRNA… expression can be associated with or even cause diseases in humans, including cancer, …

Therapeutic strategies for miRNA delivery to reduce hepatocellular carcinoma

B Roy, S Ghose, S Biswas - Seminars in Cell & Developmental Biology, 2022 - Elsevier
… The second challenge concerns the efficiency with which miRNA therapeutic agents can
target cancerous cells. How can the specificity in terms of the target tissue and cell type be …

MicroRNA replacement therapy in cancer

H Mollaei, R Safaralizadeh… - Journal of cellular …, 2019 - Wiley Online Library
… The systemic miRNA delivery strategy is a significant progress to overcome the … of miRNA
delivery in vivo and elevate the impact of cancer therapy. Up to now, different systemic delivery

Challenges identifying efficacious miRNA therapeutics for cancer

M Segal, FJ Slack - Expert opinion on drug discovery, 2020 - Taylor & Francis
miRNA-based drugs. We also review numerous in vivo delivery strategies and show examples
of the clinical development of miRNA-targeting therapeutics. By focusing on their role in …