… In this article, we first review the different types of nanotheranostic particles and their use in
imaging, followed by the biological barriers they must bypass to reach the target cancer cells, …

… The agent must also be able to penetrate through any biological barrier encountered, en
route to the intended tissue or organ while having no significant toxic side effects [52]. A …

… The major challenges in successful clinical translation of tumor specific nanoparticle delivery
include overcoming various biological barriers and demonstrating enhanced therapeutic …

… Smaller size with the multiple functionalities and higher surface to volume ratio could enable
the material to penetrate various biological barriers and efficiently target metastatic tumors, …

… With such shortcoming associated with independent cancer therapy and diagnosis, a new
field of nanotheranostics has surfaced recently as an alternative approach. ‘Theranostics’ is a …

… across biological barriers causing alteration of … for nano theranostics in imaging and cancer
therapy, particularly for clinical interest. Figure 2 depicts the various types of nanotheranostics…

… An increased interstitial fluid pressure (IFP) in many tumours represents a barrier for
transcapillary transport of nanotheranostics. Nonspecific uptake by stromal cells, such as tumour-…

… due to the systemic biological barriers, including blood … barriers by the novel design of smart
and bioinspired systems for highly efficient theranostics of various diseases, such as cancers…

… Further, it also leads to site-specific drug delivery thereby reducing the accumulation of
the drug in healthy tissues and also overcoming several biological barriers thus reducing the …

… barriers for efficient delivery of therapeutic and diagnostic agents into tumor cells. Additional
biological barriers … with resistance, and the presence of cancer stem cells within the tumor. …