… Thus, a better understanding of PGE2 signaling could … cyclooxygenase enzymes. We review
the emerging molecular mechanisms by which COX-2–derived PGE2 is involved in cancer …

… COX-2, but not in the cell line that did not express COX-2, which supports our findings.
Altogether, these studies support the use of COX-2 inhibitors in esophageal cancer prevention …

… clinicaldevelopment of one target for cancer prevention, the COX-2 enzyme. Thisprovides an
… targets will emergethat will provide even more effective drugs for future cancer prevention. …

… of COX activity) for colorectal cancers (CRCs). COX-2, the inducible isoform of cyclooxygenase,
is … and pathways by which COX-2 plays an important role in carcinogenesis. Selective …

… the potential efficacy of selective COX-2 inhibitors in preventing and treating human cancers.
Here, we focus on the rationale for using selective COX-2 inhibitors as anti-cancer agents. …

… cancer. On the other hand, it appears possible to avoid many NSAID-dependent side effects
by selective inhibition of Cox-2, … of Cox-1 and Cox-2 gene expression, we review how Cox-2 …

… to COX-2 as an important indicator in the genesis of breast cancer and discuss planned and
… clinical trials evaluating specific COX-2 inhibitors in the treatment and prevention of breast …

… The potential for cyclo-oxygenase inhibition in cancer prevention and treatment is founded
… Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer …

… Finally IGF activates the PI3 kinase/Akt/PKB-signaling cassette, enhancing translation of COX
2 … COX-2 expression [40]. Together, activation of these pathways explains the high COX-2 …

… that has no COX2 blocking activity) for comparison with selective COX-2 … cyclooxygenase
inhibitors in colon cancer prevention. In: RE Harris (ed), COX-2 Blockade in Cancer Prevention …