Curcumin―the paradigm of a multi-target natural compound with applications in cancer prevention and treatment

MH Teiten, S Eifes, M Dicato, M Diederich - Toxins, 2010 - mdpi.com
… complex human diseases such as cancer. Taking advantage of the … natural compounds in
traditional medicine, researchers started to evaluate the anti-tumor effect of natural compounds

Multi-target approach for natural products in inflammation

A Koeberle, O Werz - Drug discovery today, 2014 - Elsevier
… whether the bioactivity of the compound is lost in animal models … might succeed for multi-target
natural products if the target … colon cancer xenografts showed reduced tumor burden upon …

Phytocompounds from the medicinal and dietary plants: Multi-target agents for cervical cancer prevention and therapy

S Shoaib, N Islam, N Yusuf - Current Medicinal Chemistry, 2022 - ingentaconnect.com
… , a general term for compounds produced from plants, have gained attention for their role in
preventing cervical cancer. This role in cervical cancer prevention has garnered attention on …

The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile

A Maruca, R Catalano, D Bagetta, F Mesiti… - European journal of …, 2019 - Elsevier
natural products of the Mediterranean area are discussed, with particular attention on their
anti-cancer properties endowed with multi-target … area products in cancer prevention and their …

Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues

LRP de Siqueira, PAT de Moraes Gomes… - European Journal of …, 2019 - Elsevier
… thiazolidinones displayed that these compounds target several pathways in cancer cells. A
… of these multi-target structures in the framework development of future drugs for tumor cells, …

Flavonoids as multi-target compounds: a special emphasis on their potential as chemo-adjuvants in cancer therapy

AG Namdeo, SHS Boddu, H Amawi… - Current …, 2020 - ingentaconnect.com
… weight, naturally occurring or synthetic or semi-synthetic compounds. Natural flavonoids
are … Designing a broadspectrum integrative approach for cancer prevention and treatment. …

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

P Poornima, JD Kumar, Q Zhao, M Blunder… - Pharmacological …, 2016 - Elsevier
… Most natural products exert their bioactivity by attacking … the emergence of multi-target
specific compounds, as they … to address them by multi-target specific natural compounds [127]. …

[HTML][HTML] Marine natural products for multi-targeted cancer treatment: A future insight

MS Kumar, KM Adki - Biomedicine & Pharmacotherapy, 2018 - Elsevier
… these sponges for their future application in cancer prevention and cure. But due to limited
… bioinformatics on evolution of cancer, we may provide new facet to multi-target therapies for …

Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

E Plazas, DR Muñoz - Pharmacological Research, 2022 - Elsevier
… relevance and multi-target potential of natural isoquinolines, … as Alzheimer, Parkinson, and
Cancer. Selected examples were … in the multi-target characteristics of natural products, among …

A multi-target approach for the discovery of anti breast cancer agents from plants secondary metabolites

F Olawale, O Iwaloye, OO Elekofehinti… - Letters in Drug …, 2021 - ingentaconnect.com
… Conclusion: This study thus provides insight into multi-target protein compounds which
could be explored as chemotherapeutic alternatives in breast cancer treatment. …