Genetic testing and cancer risk management recommendations by physicians for at-risk relatives
SE Plon, HP Cooper, B Parks, SU Dhar, PA Kelly… - Genetics in …, 2011 - nature.com
… However, the recommendations for a deleterious BRCA1 mutation carrier were significantly
more intense than the VUS result. Thus, the majority of physician respondents demonstrate …
more intense than the VUS result. Thus, the majority of physician respondents demonstrate …
Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality
… mutation carriers have cancer risk–management options that include risk-reducing
salpingo-oophorectomy, risk… of breast cancer, the risk reduction in BRCA1 mutation carriers was a …
salpingo-oophorectomy, risk… of breast cancer, the risk reduction in BRCA1 mutation carriers was a …
Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management
D Ramsoekh, A Wagner, ME van Leerdam… - Hereditary cancer in …, 2009 - Springer
… mutated MMR gene has a distinguishable cancer risk profile. Female MSH6 mutation
carriers have a lower CRC risk and a higher risk for developing endometrial carcinoma. Starting …
carriers have a lower CRC risk and a higher risk for developing endometrial carcinoma. Starting …
Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007
GF Schwartz, KS Hughes, HT Lynch, CJ Fabian… - Cancer, 2008 - Wiley Online Library
… Female mutation carriers are believed to have a 25% to 50% lifetime breast cancer risk,
although data to support this level of risk is not robust. In sporadic breast cancers, it is not …
although data to support this level of risk is not robust. In sporadic breast cancers, it is not …
Breast Cancer Risk Following Bilateral Oophorectomy in BRCA1 and BRCA2 Mutation Carriers: An International Case-Control Study
A Eisen, J Lubinski, J Klijn, P Moller… - Journal of clinical …, 2005 - ascopubs.org
… of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with …
, the reduction in breast cancer risk appeared to be greatest for BRCA1 mutation carriers who …
, the reduction in breast cancer risk appeared to be greatest for BRCA1 mutation carriers who …
A Multi-Case Report of the Pathways To and Through Genetic Testing and Cancer Risk Management for BRCA Mutation-Positive Women Aged 18–25
LM Hoskins, A Werner-Lin - Journal of Genetic Counseling, 2013 - Springer
… mutation carriers and 45–55 % of BRCA2 mutation carriers … through cancer risk counseling
and management observed in … , contextual influences, risk management decisions and …
and management observed in … , contextual influences, risk management decisions and …
Risk Management for BRCA1/BRCA2 Mutation Carriers Without and With Breast Cancer
CB Mainor, C Isaacs - Current breast cancer reports, 2020 - Springer
… management for unaffected BRCA1/2 mutation carriers and the local management of
early-stage breast cancer… There is ongoing debate about uterine cancer risk in mutation carriers. …
early-stage breast cancer… There is ongoing debate about uterine cancer risk in mutation carriers. …
Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program
MS Brose, TR Rebbeck, KA Calzone… - … the National Cancer …, 2002 - academic.oup.com
… These clinics were specifically designated as breast cancer risk assessment services; thus,
… and ovarian cancer risk for BRCA1 mutation carriers from a cancer risk evaluation program in …
… and ovarian cancer risk for BRCA1 mutation carriers from a cancer risk evaluation program in …
Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations
C Julian-Reynier, J Mancini, E Mouret-Fourme… - European Journal of …, 2011 - nature.com
… cancer risk perception in non-carriers compared with carriers. Only one study has shown
that carriers' risk … breast/ovarian cancer risks vs preventive strategies and mutation carrier/non-…
that carriers' risk … breast/ovarian cancer risks vs preventive strategies and mutation carrier/non-…
Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE
N Mavaddat, S Peock, D Frost, S Ellis… - … the National Cancer …, 2013 - academic.oup.com
… In addition therapies associated with the first breast cancer may be responsible for risk
reduction, rather than oophorectomy per se. A potential shortcoming of this study is lack of data …
reduction, rather than oophorectomy per se. A potential shortcoming of this study is lack of data …