… However, the recommendations for a deleterious BRCA1 mutation carrier were significantly
more intense than the VUS result. Thus, the majority of physician respondents demonstrate …

… mutation carriers have cancer risk–management options that include risk-reducing
salpingo-oophorectomy, risk… of breast cancer, the risk reduction in BRCA1 mutation carriers was a …

… mutated MMR gene has a distinguishable cancer risk profile. Female MSH6 mutation
carriers have a lower CRC risk and a higher risk for developing endometrial carcinoma. Starting …

… Female mutation carriers are believed to have a 25% to 50% lifetime breast cancer risk,
although data to support this level of risk is not robust. In sporadic breast cancers, it is not …

… of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with …
, the reduction in breast cancer risk appeared to be greatest for BRCA1 mutation carriers who …

… mutation carriers and 45–55 % of BRCA2 mutation carriers … through cancer risk counseling
and management observed in … , contextual influences, risk management decisions and …

… management for unaffected BRCA1/2 mutation carriers and the local management of
early-stage breast cancer… There is ongoing debate about uterine cancer risk in mutation carriers. …

… These clinics were specifically designated as breast cancer risk assessment services; thus,
… and ovarian cancer risk for BRCA1 mutation carriers from a cancer risk evaluation program in …

… cancer risk perception in non-carriers compared with carriers. Only one study has shown
that carriers' risk … breast/ovarian cancer risks vs preventive strategies and mutation carrier/non-…

… In addition therapies associated with the first breast cancer may be responsible for risk
reduction, rather than oophorectomy per se. A potential shortcoming of this study is lack of data …