Clinical management of prostate cancer in high-risk genetic mutation carriers
… Various testing panels assess many germline mutations, but we will consider the main
elevation in prostate cancer risk to occur among individuals with germline mutations in (1) BRCA 1…
elevation in prostate cancer risk to occur among individuals with germline mutations in (1) BRCA 1…
Preventing breast and ovarian cancers in high‐risk BRCA1 and BRCA2 mutation carriers
, … for Research into Familial Breast Cancer … - Medical Journal of …, 2013 - Wiley Online Library
… complete 18 to maximise breast cancer risk reduction, particularly for BRCA1 mutation
carriers whose ovarian cancer risk is elevated above the general population risk by age 40. Thus …
carriers whose ovarian cancer risk is elevated above the general population risk by age 40. Thus …
Choice of management of southern Chinese BRCA mutation carriers
A Kwong, CHN Wong, C Shea, DTK Suen… - World journal of …, 2010 - Springer
… of risk … mutation carriers and the likelihood of prophylactic salpingo-oophorectomy and
tamoxifen being more significant in risk reduction of breast cancer in BRCA2 mutation carriers. In …
tamoxifen being more significant in risk reduction of breast cancer in BRCA2 mutation carriers. In …
Variation in breast cancer risk in BRCA1 and BRCA2 mutation carriers
TR Rebbeck, SM Domchek - Breast Cancer Research, 2008 - Springer
… on breast cancer risk in BRCA1/2 mutation carriers is largely … ) and reproductive history may
alter breast cancer risk [14–17]. … Individualized risk assessment is the holy grail of the human …
alter breast cancer risk [14–17]. … Individualized risk assessment is the holy grail of the human …
Risk assessment and management of high risk familial breast cancer
… A more recent large multicentre study 63 showed that this risk reduction in BRCA1/2 mutation
carriers may be as high as 90-95%. It has also been shown that in women with a BRCA1/2 …
carriers may be as high as 90-95%. It has also been shown that in women with a BRCA1/2 …
The genetic basis of familial adenomatous polyposis and its implications for clinical practice and risk management
ML Leoz, S Carballal, L Moreira, T Ocaña… - The application of …, 2015 - Taylor & Francis
… review has shown that monoallelic mutation carrier frequency was greater for cases … ),
suggesting that monoallelic carriers with a family history of CRC may be at a greater risk. …
suggesting that monoallelic carriers with a family history of CRC may be at a greater risk. …
BRCA1 and BRCA2: the genetic testing and the current management options for mutation carriers
M Palma, E Ristori, E Ricevuto, G Giannini… - Critical Reviews in …, 2006 - Elsevier
… sharp reduction of breast cancer incidence at menopause in BRCA1 mutation carrier women,
… ASCO recommendations for genetic testing for cancer risk assessment indicate that testing …
… ASCO recommendations for genetic testing for cancer risk assessment indicate that testing …
BRCA‐associated ovarian cancer: from molecular genetics to risk management
G Girolimetti, AM Perrone, D Santini… - BioMed research …, 2014 - Wiley Online Library
… of both breast and ovarian cancer; such risks are consistently estimated to be higher in …
mutation carriers; moreover, the risk is higher for breast than for OC. Estimates of cancer risk are …
mutation carriers; moreover, the risk is higher for breast than for OC. Estimates of cancer risk are …
Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers
X Wang, VS Pankratz, Z Fredericksen… - Human molecular …, 2010 - academic.oup.com
… assessment for BRCA1 and BRCA2 carriers (18). Thus, in subsequent risk assessment
studies, we … to cancer risk assessment in BRCA1 and BRCA2 carriers. Initially, the proportion of …
studies, we … to cancer risk assessment in BRCA1 and BRCA2 carriers. Initially, the proportion of …
Modifiers of breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers
RL Milne, AC Antoniou - Endocrine-related cancer, 2016 - erc.bioscientifica.com
… However, parallel to the analytical and methodological work required to develop cancer
risk prediction models and risk assessment tools specifically for BRCA1 and BRCA2 …
risk prediction models and risk assessment tools specifically for BRCA1 and BRCA2 …