… Various testing panels assess many germline mutations, but we will consider the main
elevation in prostate cancer risk to occur among individuals with germline mutations in (1) BRCA 1…

… complete 18 to maximise breast cancer risk reduction, particularly for BRCA1 mutation
carriers whose ovarian cancer risk is elevated above the general population risk by age 40. Thus …

… of risk … mutation carriers and the likelihood of prophylactic salpingo-oophorectomy and
tamoxifen being more significant in risk reduction of breast cancer in BRCA2 mutation carriers. In …

… on breast cancer risk in BRCA1/2 mutation carriers is largely … ) and reproductive history may
alter breast cancer risk [14–17]. … Individualized risk assessment is the holy grail of the human …

… A more recent large multicentre study 63 showed that this risk reduction in BRCA1/2 mutation
carriers may be as high as 90-95%. It has also been shown that in women with a BRCA1/2 …

… review has shown that monoallelic mutation carrier frequency was greater for cases … ),
suggesting that monoallelic carriers with a family history of CRC may be at a greater risk. …

… sharp reduction of breast cancer incidence at menopause in BRCA1 mutation carrier women,
… ASCO recommendations for genetic testing for cancer risk assessment indicate that testing …

… of both breast and ovarian cancer; such risks are consistently estimated to be higher in …
mutation carriers; moreover, the risk is higher for breast than for OC. Estimates of cancer risk are …

… assessment for BRCA1 and BRCA2 carriers (18). Thus, in subsequent risk assessment
studies, we … to cancer risk assessment in BRCA1 and BRCA2 carriers. Initially, the proportion of …

… However, parallel to the analytical and methodological work required to develop cancer
risk prediction models and risk assessment tools specifically for BRCA1 and BRCA2 …