Association between epithelial‐mesenchymal transition and cancer stemness and their effect on the prognosis of lung adenocarcinoma

T Sowa, T Menju, M Sonobe, T Nakanishi… - Cancer …, 2015 - Wiley Online Library
cancer stem cells in solid tumors, such as breast cancer 14, colon cancer 15, pancreatic
cancer … shown that CD133 has an important role in tumor progression in lung adenocarcinoma. …

[HTML][HTML] Inhibition of DCLK1 sensitizes resistant lung adenocarcinomas to EGFR-TKI through suppression of Wnt/β-Catenin activity and cancer stemness

R Yan, X Fan, Z Xiao, H Liu, X Huang, J Liu, S Zhang… - Cancer letters, 2022 - Elsevier
… relationship between DCLK1 and the stemness of lung adenocarcinoma cells. In resistant …
, the most relevant pathway for maintaining tumor cell stemness, was significantly activated in …

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

WJ Chen, CC Ho, YL Chang, HY Chen, CA Lin… - Nature …, 2014 - nature.com
… and CL152) derived from lung adenocarcinoma patients. … discover cancer stemness-specific
signalling pathways in lung … that of CLS1-differentiated cancer cells cultured without feeder …

NCAPG2 Maintains Cancer Stemness and Promotes Erlotinib Resistance in Lung Adenocarcinoma

S Jiang, J Huang, H He, Y Liu, L Liang, X Sun, Y Li… - Cancers, 2022 - mdpi.com
… between erlotinib resistance and stemness in lung adenocarcinoma. NCAPG2 was identified
as an erlotinib resistance gene and maintained the stemness of lung adenocarcinoma. …

[HTML][HTML] Nestin regulates proliferation, migration, invasion and stemness of lung adenocarcinoma

K Narita, Y Matsuda, M Seike… - International …, 2014 - spandidos-publications.com
… In order to clarify the effects of nestin downregulation on cell growth, migration, invasion
and stemness of lung adenocarcinoma cells, we used H1975 untreated, Sc and Sh cells. …

… invasion and visceral pleural invasion and their correlations with epithelial–mesenchymal transition, cancer stemness, and treatment failure in lung adenocarcinoma

S Neri, T Menju, T Sowa, Y Yutaka, D Nakajima… - Lung Cancer, 2019 - Elsevier
… Epithelial–mesenchymal transition (EMT) and cancer stemness (CS) of cancer cells are …
Cancer stem cells (or cancer-initiating cells) possess stem cell-like properties such as self-…

Wnt signaling regulates the stemness of lung cancer stem cells and its inhibitors exert anticancer effect on lung cancer SPC-A1 cells

X Zhang, Y Lou, H Wang, X Zheng, Q Dong, J Sun… - Medical Oncology, 2015 - Springer
cancer stem cells (CSCs) in a variety of cancers. In this study, we explored the role of Wnt
signaling in the lung cancer stem cells (… , for which human lung adenocarcinoma cell line SPC-…

Lung cancer stem cells: Molecular features and therapeutic targets

S Singh, S Chellappan - Molecular aspects of medicine, 2014 - Elsevier
… Nanog in lung adenocarcinoma progression. The high levels of Oct4 and Nanog was positively
associated with moderate and poorly differentiated grade of adenocarcinoma as well as …

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

S Lin, C Huang, J Sun, O Bollt, X Wang… - EMBO molecular …, 2019 - embopress.org
cancer progression and patient survival. The depletion of DGUOK robustly inhibited lung
adenocarcinoma tumor … Mechanistically, DGUOK is required for the biogenesis of respiratory

Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells

U Testa, G Castelli, E Pelosi - Cancers, 2018 - mdpi.com
… These differences have a considerable impact on the management of lung adenocarcinomas
at the level of regional cancer centers and of the design of clinical trials in different …