A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance

A Alkrekshi, W Wang, PS Rana, V Markovic… - Cellular signalling, 2021 - Elsevier
… Recent studies have associated YB-1 with the regulation of the malignant phenotypes in …
physiological functions of YB-1. We will also review the role of YB-1 in cancer development, …

Requirement of the transcription factor YB-1 for maintaining the stemness of cancer stem cells and reverting differentiated cancer cells into cancer stem cells

F Yang, P Cui, Y Lu, X Zhang - Stem cell research & therapy, 2019 - Springer
… showed that YB-1 maintained the stemness of cancer stem … YB-1 was required for maintaining
the stemness of cancer stem cells and reverting the differentiated tumor cells into cancer

[HTML][HTML] YB-1 interplays with ERα to regulate the stemness and differentiation of ER-positive breast cancer stem cells

F Yang, S Chen, S He, Q Huo, Y Hu, N Xie - Theranostics, 2020 - ncbi.nlm.nih.gov
… /YB-1 axis in the regulation of breast cancer stemness We further explored whether ERα
can affect the stemness of CSCs by regulating the expression of YB-1… levels of stemness-related …

YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells

K Jung, F Wu, P Wang, X Ye, BS Abdulkarim, R Lai - BMC cancer, 2014 - Springer
… putative YB-1 binding … YB-1 putative binding sites, we found evidence that YB-1 binds to
the SOX2 promoter at two adjacent regions (Figure 2B). Further, promoter DNA binding by YB-1

YBX1 enhances metastasis and stemness by transcriptionally regulating MUC1 in lung adenocarcinoma

Q Xie, S Zhao, W Liu, Y Cui, F Li, Z Li, T Guo… - Frontiers in …, 2021 - frontiersin.org
… In conclusion, our findings indicated a novel mechanism by which YBX1 promotes the
stemness and metastasis of lung adenocarcinoma by targeting MUC1 and provided a …

Folfox therapy induces feedback upregulation of cd44v6 through yb-1 to maintain stemness in colon initiating cells

S Ghatak, VC Hascall, RR Markwald… - International journal of …, 2021 - mdpi.com
… through YB-1. Further, our results revealed for the first time that CD44v6 regulated YB-1
and for the reversion of differentiated CD44v6 knockout-CICs into CICs with stemness traits. …

Shrimp miR-S8 suppresses the stemness of human melanoma stem-like cells by targeting the transcription factor YB-1

F Yang, J Wei, S Zhang, X Zhang - Cancer Research, 2017 - AACR
YB-1 had major effects on the stemness of cancer stem cells and that the expression of YB-1
… miR-S8 inhibited YB-1 expression by mediating the degradation of YB-1 mRNA. In animals, …

The interaction between PDCD4 and YB1 is critical for cervical cancer stemness and cisplatin resistance

D Liu, J Ke, Y Liu, H Rao, Z Tang, Y Liu… - Molecular …, 2021 - Wiley Online Library
YB1 was required for maintaining the stemness of cancer stem cells. So, in this study, we used
YB1 as a marker of stemness … the protein expressions of PDCD4, YB1, pYB1, and MDR1. …

[HTML][HTML] Akt3 promotes cancer stemness in triple-negative breast cancer through YB1-Snail/Slug signaling axis

Y Tian, J Li, TC Cheung, V Tam, CG Lau… - Genes & …, 2023 - ncbi.nlm.nih.gov
stemness via YB1-Snail/Slug signaling axis. To the best of our knowledge, we have identified
YB1 as … In addition, we provided direct evidence that YB1 phosphorylation promotes Snail/…

CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1

L Zhang, X Dong, B Yan, W Yu, L Shan - Cell death & disease, 2020 - nature.com
… axis to drive metastasis and stemness in CRC by sponging miR-4262 and miR-185-5p. …
LncRNA DANCR enhances stemness features via upregulation of CTNNB1 in hepatocellular …