… –MAPK pathway, the consequence of its disregulation and the development of small-molecule
inhibitors. The rationale for targeting the RAS–MAPK pathway … the RAS–MAPK molecular …

… The mitogen-activated protein kinases (MAPK) pathway, often … pathway in human cancer,
targeting the MAPK pathway has long been considered a promising strategy for cancer therapy…

… pathway is associated with anti‐apoptotic processes while activation of the JNK/p38 MAPK
pathways is … between the ERK pathway and JNK/p38 MAPK pathways determines the fate of …

… The MAPK pathway is dysregulated in many RAS-associated cancers. RAS mutations result
in the constitutive activation of the MAPK pathway, leading to uncontrolled cell proliferation …

… MAPK has implications in the response to cancer therapy, particularly the activation of the
compensatory pathways in response to experimental MAPK … of the MAPK pathways in cancer, …

… MAP kinase pathway activation. These compounds have been useful tools for identifying the
mechanisms of MAP kinase pathway … in Ras and MAP kinase signaling pathways and their …

… MAPK pathway in CRC development and chemoresistance. In our view, this might help
establish the therapeutic potential of the targeted manipulation of this pathway in clinical settings. …

… by activating ERK and p38 in the MAPK pathway and inhibiting the Akt/mTOR pathway (Bae
et al. 2013), indicating that (19Z)-HCA may be used in lung cancer therapy in the future. …

… of Ras in 1993 [12, 13], resulting in the delineation of the whole MAPK signaling pathway,
which is considered as a milestone in our understanding of how cell senses external stimuli. …

… This review outlines current understanding of p38 MAPK family members and their involvement
in tumor development, as well as the strategies to treat cancer based on targeting p38. …