Targeting PI3K/Akt signal transduction for cancer therapy
Y He, MM Sun, GG Zhang, J Yang, KS Chen… - Signal transduction and …, 2021 - nature.com
… of signaling inhibitors and conventional cancer therapies. The … signaling networks will
facilitate a better comprehension of the PI3K pathway and further exploration of cancer therapies. …
facilitate a better comprehension of the PI3K pathway and further exploration of cancer therapies. …
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
… The PAM axis is the most frequently activated signaling pathway in human cancer and is …
to anticancer therapies. Dysfunction of components of this pathway such as hyperactivity of PI3K…
to anticancer therapies. Dysfunction of components of this pathway such as hyperactivity of PI3K…
Signal transduction pathways in breast cancer: the important role of PI3K/Akt/mTOR
MA Ortega, O Fraile-Martínez, Á Asúnsolo… - Journal of …, 2020 - Wiley Online Library
… Everolimus is one of the main drugs that targets mTOR, and numerous studies have
demonstrated its effectiveness in breast cancer therapy [101]. Du et al. [102] reported the efficacy of …
demonstrated its effectiveness in breast cancer therapy [101]. Du et al. [102] reported the efficacy of …
PI3K/Akt signalling pathway and cancer
JÁF Vara, E Casado, J de Castro, P Cejas… - Cancer treatment …, 2004 - Elsevier
… response to treatment. In the present review, we discuss PI3K/Akt pathway components
and functions as well as its alteration in cancer and relationship with the different therapeutic …
and functions as well as its alteration in cancer and relationship with the different therapeutic …
Signal transduction therapy of cancer
A Levitzki, S Klein - Molecular aspects of medicine, 2010 - Elsevier
… Although there are data showing that shRNA can be used in mice, we are still a long way
from its application in human cancer therapy. Serious problems include biodistribution. …
from its application in human cancer therapy. Serious problems include biodistribution. …
PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes
… PI3K pathway deregulation is the driver in approximately 30% of all cancers. This … cells and
it plays a critical role in signal transduction in both physiologic and pathologic angiogenesis. …
it plays a critical role in signal transduction in both physiologic and pathologic angiogenesis. …
Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy
YL Chen, PY Law, HH Loh - … Medicinal Chemistry-Anti-Cancer …, 2005 - ingentaconnect.com
… However, the real breakthrough for the design of signal transduction inhibitors for cancer
therapy came from the discovery of the Abl re… This targeted cancer therapy showed very limited …
therapy came from the discovery of the Abl re… This targeted cancer therapy showed very limited …
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
J Polivka Jr, F Janku - Pharmacology & therapeutics, 2014 - Elsevier
… different types of cancer. This review focuses on targeted PI3K/AKT/mTOR signaling from
the … ‑C2γ (PIK3C2G), are ill defined in signal transduction and are generally not involved in …
the … ‑C2γ (PIK3C2G), are ill defined in signal transduction and are generally not involved in …
PI3K/Akt/mTOR pathway as a target for cancer therapy
D Morgensztern, HL McLeod - Anti-cancer drugs, 2005 - journals.lww.com
… Components of this pathway are frequently abnormal in a variety of tumors, making them
an attractive target for anti-cancer therapy. Inhibition of mTOR in patients with cancer became …
an attractive target for anti-cancer therapy. Inhibition of mTOR in patients with cancer became …
The relation between PI3K/AKT signalling pathway and cancer
… Focusing on the PI3K pathway remains both a chance and a challenge for cancer therapy. …
regulation that converge among the PI3K signal transduction pathway in an equilibrium that …
regulation that converge among the PI3K signal transduction pathway in an equilibrium that …
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