… The tumor heterogeneity is exacerbated during the progression of the cancer along with
the … and noncellular components of the tumor niche—the tumor microenvironment (TME) [4,5]. …

… tumor microenvironment to encapsulate or destroy cancer … tumor stroma, and the similarity
with normal tissue present huge challenges for therapies targeting the tumor microenvironment…

… The tumor microenvironment (TME) has received growing attention from an increasing …
organizations including the National Cancer Institute (NCI) and the American Association for …

… Mounting evidence suggests critical roles played by the tumor microenvironment (TME) in
multiple aspects of cancer progression particularly therapeutic resistance. The TME decreases …

… We highlight the potential of tumor microenvironment; its role in disease progression, …
strategies for effective cancer therapy by conceptual understanding of tumor microenvironment and …

… of the promotion of tumor. These complex … for cancer therapy, and, therefore, advancing
knowledge about dominant drivers of cancer within the TME is critical for designing therapeutic …

… Starting from the concept of viewing the tumor as a complex organ, we meanwhile use the
term tumor microenvironment (TME) to describe the entirety of the tumor components that are …

… In the majority of patients with end-stage cancer, the primary cause for treatment failure is
resistance to cancer therapy. Either primary or acquired drug resistance particularly represents …

… and opportunity to target cancer, the 3D models available to understand TME, and the
bioinformatics advancements towards profiling of tumor microenvironments for identification of …

… They function as potent signaling molecules between cancer cells and the surrounding
cells that comprise the tumor microenvironment (TME). Exosomes derived from both tumor and …