… This paper reviews three validated targets for the treatment of solid malignancies: (i) epidermal
… These three targets illustrate the potential of targeted therapy as well as the potential …

… a challenge to validate MMPs as potential drug targets. Until … 2) have been validated as
anti-tumour targets despite years of … other MMPs have been validated as cancer anti-targets, with …

… in cancers and have been associated with tumour dysfunction. With multifaceted actions, these
ectoproteases have been validated as therapeutic targets for cancer… treatment of cancers. …

… There is no doubt that the general principles of cancer therapeutics established … treatment
regimens covering multiple targets should result in improved treatment outcomes for cancer …

… identical cancer cells were used. Taken together, these studies provide >40 novel validated
targets, for new drug discovery and anti-cancer therapy. Since anabolic cancer cells amplify …

… cancer treatment. The result showed a good tolerance by the treated patients, associated
with … of tumor-related immunity, and long-term clinical responses against ovarian cancer [48]. …

… of cancer targets. We then scrutinize the utility of validation methods by analysing their impact
on the cancer … a validated target, and that our ability to predict the efficacy of a targeted …

… with cancer and their druggability for cancer therapeutics. … Although it is still early days in
terms of target validation, and our … GEFs and GAPs hold exciting prospects for cancer therapy. …

… Compound validation has relied on target validation first, … Protein kinases represent such
molecular targets; considerable … validated the positive effects of kinase inhibitors for cancer …

… were then satisfactorily validated by several ways, including known cancer genes, results of
… been used or in clinical trial in cancer treatments. TARGETgene is freely available from the …