过去一年中添加的文章，按日期排序
Computational Insights into Captopril's Inhibitory Potential Against MMP9 and LCN2 in Bladder Cancer: Implications for Therapeutic Application
SK Annana, J Ferdoush, F Lamia, A Roy… - Cancer …, 2024 - journals.sagepub.com
2 天前 - … By using DrugBank, we identified 5 primary direct protein targets (DPTs) of captopril
such as … Subsequently, we validated and visualized the interactions using Cytoscape, as …
such as … Subsequently, we validated and visualized the interactions using Cytoscape, as …
The anticancer effects of Aronia berry extract are mediated by Chk1 and p53 in colorectal cancer
2 天前 - … targets of ABE in CRC. Chk1 and p53 activation was shown to be downregulated
with ABE treatment, … Overall, ABE exerted anti-cancer activity in PDOs, successfully validating …
with ABE treatment, … Overall, ABE exerted anti-cancer activity in PDOs, successfully validating …
Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization
L Chen, Z Rong, Y Gu, Y Chen, W Yu, Y Zhou, X Pang - medRxiv, 2024 - medrxiv.org
2 天前 - … therapeutic targets for PCa prevention 19 and treatment. … , 32 including KLK3, were
validated in both the deCODE and … 36 targets for PCa, such as HSPB1, RRM2B and PSCA. …
validated in both the deCODE and … 36 targets for PCa, such as HSPB1, RRM2B and PSCA. …
Transcriptional-program-based deciphering of the MET exon 14 skipping regulation network
MJ Truong, G Pawlak, JP Meneboo, S Sebda… - bioRxiv, 2024 - biorxiv.org
2 天前 - … from MEK inhibitor-treated METex14del cells validated the key role … pathways that
may become novel therapeutic targets. … Here we constructed a lung cancer-specific regulatory …
may become novel therapeutic targets. … Here we constructed a lung cancer-specific regulatory …
Network-based estimation of therapeutic efficacy and adverse reaction potential for prioritisation of anti-cancer drug combinations
2 天前 - … validation. Here we present a novel network medicine approach that systematically
models the proximity of drug targets … drug combinations for cancer treatment starting from a …
models the proximity of drug targets … drug combinations for cancer treatment starting from a …
[HTML][HTML] Ding-Zhi-Xiao-Wan decoction alleviates mitochondrial autophagy in vascular dementia mice via the PI3K/Akt/mTOR pathway
M Deng, X Zhong, Z Ning, Y Wang, D Hu, H Zhang… - Phytomedicine Plus, 2024 - Elsevier
3 天前 - … Normal saline or DZXW was administered to Institute of Cancer Research mice via
… of the mice post-treatment. To validate potential targets and efficacy mechanisms identified …
… of the mice post-treatment. To validate potential targets and efficacy mechanisms identified …
An in vitro assessment of ionizing radiation impact on the efficacy of radiotherapy for breast cancer
M Girgin, A Akat, B Akgül, N Nalbant… - Turkish Journal of …, 2024 - degruyter.com
3 天前 - … targets for improving radiation therapy effectiveness. Modulating the expression of
these miRNAs could enhance cancer treatment by making cancer … prioritize the validation of …
these miRNAs could enhance cancer treatment by making cancer … prioritize the validation of …
[HTML][HTML] Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders
H Zhou, D Balint, Q Shi, T Vartanian… - Annals of the …, 2024 - ard.bmj.com
3 天前 - … -like proteins and their targets in key signalling pathways. … We included four published
colorectal cancer (CRC) datasets … Second, we employ n-fold cross-validation to test the …
colorectal cancer (CRC) datasets … Second, we employ n-fold cross-validation to test the …
Drug response-based precision therapeutic selection for tamoxifen-resistant triple-positive breast cancer
4 天前 - … Effect of selected drug inhibitors against druggable targets Selected proteomic
targets were therapeutically validated using a drug-dose response curve. Sulphorhodamine B (…
targets were therapeutically validated using a drug-dose response curve. Sulphorhodamine B (…
Computational Analysis Shows Strong Interactions between Snake Venom Molecules and Cell Receptors
E Akat Çomden, ES Koçkaya, H Can - Ecem Su and Can, Hüseyin … - papers.ssrn.com
4 天前 - … toxicity mechanisms and identifying therapeutic targets. This study used ClusPro
and … against snake envenomation and cancer. Further experimental validation is needed to …
and … against snake envenomation and cancer. Further experimental validation is needed to …