… phenotype in cancer presentation and response to treatment. … pathways that are essential
to cancer cell behavior. miRNA … in colon cancer was later validated in an independent cohort. …

… Returning to our earlier metaphor, we must specifically scramble the language of the cancer
… targets defined by genomics. And to do that we need to identify and validate the drug targets…

… Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that …
5 benign prostate tissue (BEN) samples and validated findings in tumors from a large cohort of …

… Furthermore, we show that this specific kinase profile is validated … targets for the treatment
of ER-negative breast cancer, including the aggressive triple-negative form of breast cancer. …

… The identification of PIK3CA validated our approach to identify kinases that are essential for
… cancer treatment are based on existing targets. Rather than reflecting an absence of targets, …

… of cancer. As they can act as either oncogenes or tumor suppressors, miRNAs have been
proposed as potential new therapeutic targets or tools for cancer … to the treatment with cytotoxic …

… These include using different methods to validate novel targets and identify chemical …
targets. Although we should continue to explore the cancer genome for novel tractable targets …

… cancer cell survival. We recently presented comprehensive gene expression signatures of
colorectal cancer … thus, may represent candidate molecular targets, we first identified CRC cell …

… -treated transcriptional response data derived from CMap was provided as a promising
strategy for repositioning of approved and generic drugs for alternate uses in cancer treatment. …

… of whether ABC transporters mediate drug resistance in cancer through a reduction in drug
… only been validated in model systems. Possible explanations for the failure to validate this …