… Proteins in these pathways were validated as targets and new drugs were developed, some
… of cancer therapeutics (Figure 1). As we learn more about tumours, many new targets are …

… robustly standardized and validated assays are required. … mechanism for colorectal cancer
patients treated with anti-… cell niche in cancer; Wnt activity in colorectal cancer stem cells …

… information for the validation of specific CDK variants as potential targets in cancer therapy.
… cell cycle machinery have been investigated as cancer drug targets. These include the cyclin-…

… The fourth compound that has played an important role in the validation of Aurora kinases
as potent therapeutic targets is PHA-680632 (Nerviano). It induces a biological response …

… Many developers of drugs now rely on experimental primarily target-based approaches
including so-called high-throughput screening procedures using genetic tools to validate targets. …

… targets to impair cancer cell growth and enhance treatment … of cancer and explore their
potential as therapeutic targets. … /BRUCE, as new cancer therapeutic targets. Results collected …

… in cancer that have been well studied as targets for drug … these current targets, their potential
application for cancer drug … the identification and validation of some targets discussed in this …

… heterozygous strain carried a deletion of the well validated, direct binding protein target of
the … In this study, the investigators successfully identified many well-validated targets of small …

… An extremely small number of microRNA targets have been validated previously, thus
analyses of microRNA–target relationship relies on in silico predictions. Simultaneous use of …

… However, lack of readily accessible tumor tissue in patients with PDA significantly
challenges serial sampling of tumors in treated patients for in vivo target validation studies. …