Functional and structural diversity in the Als protein family of Candida albicans
DC Sheppard, MR Yeaman, WH Welch… - Journal of Biological …, 2004 - ASBMB
… Using this model system, we demonstrated that Als proteins … Als proteins are closely related
in structure to adhesin and invasin members of the immunoglobulin superfamily of proteins. …
in structure to adhesin and invasin members of the immunoglobulin superfamily of proteins. …
The ALS gene family of Candida albicans
LL Hoyer - Trends in microbiology, 2001 - cell.com
… of particular ALS genes in certain isolates, and additional ALS coding … ALS genes results
in a diverse cell-surface Als protein profile that is also affected by growth conditions. The ALS …
in a diverse cell-surface Als protein profile that is also affected by growth conditions. The ALS …
Candida albicans Agglutinin-Like Sequence (Als) Family Vignettes: A Review of Als Protein Structure and Function
LL Hoyer, E Cota - Frontiers in microbiology, 2016 - frontiersin.org
… information about C. albicans Als proteins, their true functional relatedness is still relatively
unexplored and the phenotypes observed may be heavily influenced by protein abundance …
unexplored and the phenotypes observed may be heavily influenced by protein abundance …
Candida albicans Als proteins mediate aggregation with bacteria and yeasts
SA Klotz, NK Gaur, R De Armond, D Sheppard… - Medical …, 2007 - academic.oup.com
… We therefore performed this study to determine to what extent the fungal cell surface Als
proteins of C. albicans might contribute to the formation of mixed microbial aggregates. …
proteins of C. albicans might contribute to the formation of mixed microbial aggregates. …
Identification of Candida albicans ALS2 andALS4 and Localization of Als Proteins to the Fungal Cell Surface
LL Hoyer, TL Payne, JE Hecht - Journal of bacteriology, 1998 - Am Soc Microbiol
… Alignment of five predicted Als protein sequences indicated conservation of N- and C-terminal …
four other Als proteins analyzed, suggesting identical processing of each protein. Primary-…
four other Als proteins analyzed, suggesting identical processing of each protein. Primary-…
Detection of Als Proteins on the Cell Wall ofCandida albicans in Murine Tissues
LL Hoyer, J Clevenger, JE Hecht, EJ Ehrhart… - Infection and …, 1999 - Am Soc Microbiol
… These observations further strengthen our conclusion of cell wall localization for Als proteins
(9) and suggest that Als proteins are continuously present on the surface of C. albicans …
(9) and suggest that Als proteins are continuously present on the surface of C. albicans …
Candida albicans Als Adhesins Have Conserved Amyloid-Forming Sequences
… Therefore, we determined whether Als proteins could form amyloid fibers with properties …
conserved in Als proteins and evolve more slowly than other regions of the proteins. Therefore, …
conserved in Als proteins and evolve more slowly than other regions of the proteins. Therefore, …
Evaluation of the Role of Candida albicans Agglutinin-Like Sequence (Als) Proteins in Human Oral Epithelial Cell Interactions
C Murciano, DL Moyes, M Runglall, P Tobouti, A Islam… - PloS one, 2012 - journals.plos.org
… The goal of this work was to investigate the role of Als proteins in epithelial adhesion and
damage, and cytokine production. We also evaluated whether Als3 is the moiety that mediates …
damage, and cytokine production. We also evaluated whether Als3 is the moiety that mediates …
Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family — a sticky pursuit
LL Hoyer, CB Green, SH Oh, X Zhao - Medical mycology, 2008 - academic.oup.com
… Candida albicans ALS1 was first described … ALS genes and exploring the function of the
Als proteins. Functional studies have focused primarily on the hypothesis that Als proteins are C. …
Als proteins. Functional studies have focused primarily on the hypothesis that Als proteins are C. …
Comprehensive Analysis of Glycosylphosphatidylinositol-Anchored Proteins in Candida albicans
ML Richard, A Plaine - Eukaryotic cell, 2007 - Am Soc Microbiol
… Other than the Als proteins, Hwp1 is one of the most studied proteins and probably the …
Moreover, Hwp1 and Als proteins both appear to act on the same aspect of C. albicans biology: …
Moreover, Hwp1 and Als proteins both appear to act on the same aspect of C. albicans biology: …
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