… the feasibility of developing highly effective malaria vaccines, the precise antigens that induce
… applied to vaccine candidate discovery for Plasmodium falciparum malaria from the pre- to …

… system to build an effective vaccine. In this article, we describe candidate antigens, mechanisms,
targets and trials performed with potential malaria vaccines and discuss the approaches…

… has further demonstrated the feasibility of vaccination as protection against malaria. …
vaccines against malaria, no strong vaccine candidate has emerged as yet. Most vaccine …

… a highly effective malaria vaccine. The vaccine RTS,S/AS01, the first ever malaria vaccine
to enter Phase III clinical trials and the first human parasitic vaccine ever created, shows …

… Next-generation malaria vaccine … novel malaria vaccine candidates and the direction of
development of efficacious next-generation vaccines in line with the revised strategic goals of the …

… clinical malaria, and ii) vaccines … malaria vaccine RTS,S/AS01 was the first malaria vaccine
to enter Phase III clinical trials and shows modest efficacy against clinical falciparum malaria (…

… Until recently, malaria vaccine development efforts have … century, a successful malaria vaccine
remains elusive. Sequencing … approaches to discover candidate vaccine antigens. We are …

… of malaria vaccine development, focusing in particular on those candidate vaccines that will
… A summary of the vaccines discussed in this review is shown in Table 1. All volunteers were …

… In the present work, we review the main vaccine candidates against malaria proposed to
date, their characteristics, and some of their limitations, focused on new approaches that could …

… trials of the malaria vaccine candidates that had preceded it – … of CS-based vaccines that
employed a variety of vaccine delivery … These candidates had been tested in the clinic and were …