… made in the treatment of metastatic colorectal cancer (mCRC) due to the approval of new …
for the management of metastatic mCRC and discuss new candidate targets on the horizon. …

… fast track mechanism with a target enrollment of 430 patients. … This study is expected to reach
its target patient enrollment in … With respect to novel candidate targeted agents, we eagerly …

Colorectal cancer (CRC) is the third leading cause of cancer deaths, and while mortality has
largely improved in the developed world, five-year survival for metastatic disease remains …

… There is a growing need for clinical and preclinical research aimed at identifying new
targets for the selective treatment of mCRC. Among the new tumor targets under development, …

… in CRC are the ones that target the vascular endothelial growth factor (… target the EGFR,
have been approved for the treatment of … as affecting candidate genes involved in colon tumor …

… Therefore, the EGFR pathway constitutes an important target for cancer therapy. In this …
metastasis in colon cancer has to be determined, there are already promising candidates …

… in short treatment durations compared to first-line therapy [21]. … who may become candidates
for metastatic resection and … and treatment goals are heterogeneous in first-line therapy, …

… that the goal of individualized treatment is … therapy on metastatic sites. PTEN status and
the significance of PTEN in the metastatic lesions therefore represent promising candidates …

… of the most important therapeutic targets for mCRC treatment, and various strategies, …
treatment of patients with metastatIC colorectal cancer who are not candidatE for intensive therapy) …

… into the therapeutic armamentarium, since the decision of which patients are good
candidate for anti-VEGF target therapy is actually based only on gross clinical characteristics. …