… This class of antimicrobials has a broader spectrum … molecular structure: the carbapenems
together with the β-lactams. This combination gives an extraordinary stability to the molecule …

… current knowledge on carbapenem resistance in Enterobacteriaceae… molecular classes of
β-lactamases has been identified in Enterobacteriaceae: the Ambler class A, class B and class …

… Generally, Klebsiella pneumoniae carbapenemase (KPC)-producing carbapenemases in
the β-lactamase molecular class A are rare, however, the variants are rapidly spreading, with …

… classes which include Ambler classes A, B, and D. Several mobile genetic elements (MGEs)
have their potential role in carbapenem resistance like Tn4401, Class … through molecular or …

… production of outer-membrane porins, together with increased expression of a class C
cephalosporinase, appear to be important factors leading to carbapenem resistance in this region. …

… series encoded ESBL enzymes from Ambler classes A (SME, CTX-M, … The carbapenem
resistance phenotype in Case 2 was … Class A and C resistance genes (bla CTX-M in Case 5 and …

… Ambler's structural classification comprises four molecular classes: A) The Extended …
carbapenem resistance is commonly associated with resistance to other antibiotic classes. …

… is a growing literature on carbapenem resistance. Some early reports described … carbapenem
resistance (6, 11, 23), but most recent reports describe β-lactamase-mediated resistance…

… The MHT used to identify carbapenemases is laborious, unable to differentiate between
different classes of carbapenemases, and lacks sensitivity (61–100 %) and specificity [14–16]. …

… Genes coding for Ambler class B carbapenemases and class A serine enzymes were detected
by … PCR amplification of class 1 integrons and analysis of the genetic context of resistance …