… activity (IC 50 ) was determined by spectrophotometric assay at 37C. Moreover, inhibition of
enzymatic activity … residual β-lactamase activity after incubation of the OXA-24 extract for 10 …

… must arise between OXA-24, a class D oxacillinase with carbapenemase activity, and
structurally … activity toward carbapenems as well as its apparent lack of activity against oxacillin). …

… OXA-24/40 structure and that was suggested to be responsible for the carbapenemase activity
of … loop is predominantly phenylalanine (the OXA-24/40-like and OXA-143-like subfamilies …

… carbapenemases, namely the intrinsic (OXA-51) and the acquired (OXA-23 and/or OXA-24).
Class D oxacillinases were the only enzymes with carbapenemase activity detected in the …

… developed; it detects carbapenemase activity with very high … in the CLSI guidelines for
carbapenemase activity detection. … -lactamases with low carbapenemase activity, such as OXA-48-…

… by OXA-27 and -23 but was replaced by KSG in OXA-24, -25, … , -25, -26, and -27 have only
feeble carbapenemase activity, … greater carbapenemase activity than the present OXA types, …

… related to either the OXA-23 or the OXA-24 families. A … that do not show carbapenemase
activity and vice versa. … for the carbapenemase activity of the OXA-type carbapenemases. Rather…

… interfere with formation of the Δ 1 -tautomer of carbapenem antibiotics (as observed in the
OXA-1-doripenem complex) and thus is critical for the carbapenemase activity of OXA-24 ( …

… inhibit many β-lactamases.27, 33, 34 Is it therefore possible that the lack of doripenem
tautomerization on OXA-24 is responsible for the carbapenemase activity of this enzyme? …

… with OXA-232 and OXA-244). On the other hand, few OXA-48 variants lacking significant
carbapenemase activity (… -related OXA carbapenemases (10 OXA-23-like, 13 OXA-24/-40-like, 5 …