Visualization of the cocaine-sensitive dopamine transporter with ligand-conjugated quantum dots
… used an organic dye-conjugated 2β-carbomethoxy-3β-(3,4-… β-CFT is a structural analogue
of cocaine, is 3–10× more … of the use of radiolabeled β-CFT to map DAT distribution in …
of cocaine, is 3–10× more … of the use of radiolabeled β-CFT to map DAT distribution in …
Performance on an Alzheimer-selective odor identification test in patients with Parkinson's disease and its relationship with cerebral dopamine transporter activity
… brain DAT [ 11 C]β-CFT (2-β-carbomethoxy-3β-(4-fluorophenyl) … In this study, dynamic [ 11
C]β-CFT DAT PET imaging with … [ 11 C]β-CFT binding potential (BP) was calculated using a …
C]β-CFT DAT PET imaging with … [ 11 C]β-CFT binding potential (BP) was calculated using a …
[11C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain
C Halldin, N Erixon-Lindroth, S Pauli, YH Chou… - European journal of …, 2003 - Springer
… The cocaine congener β-CIT [2β-carbomethoxy-3β-(4-… , β-CFT, is a more selective DAT
ligand and has been labelled with either 11 C or 18 F [23, 24]. In vivo, [ 11 C/ 18 F]β-CFT reaches …
ligand and has been labelled with either 11 C or 18 F [23, 24]. In vivo, [ 11 C/ 18 F]β-CFT reaches …
in vivo Presynaptic and Postsynaptic Striatal Dopamine Functions in Idiopathic Normal Pressure Hydrocephalus
Y Ouchi, T Nakayama, T Kanno… - Journal of Cerebral …, 2007 - journals.sagepub.com
… CFT ([ 11 C]2-β-carbomethoxy-3β-(4-fluorophenyl) tropane) that binds to dopamine transporter
and a postsynaptic marker [ 11 C]raclopride that binds to D2 receptor. Quantitative values …
and a postsynaptic marker [ 11 C]raclopride that binds to D2 receptor. Quantitative values …
Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment
YI Chen, AL Brownell, W Galpern, O Isacson… - …, 1999 - journals.lww.com
… transporter ligands amphetamine and CFT (2β-carbomethoxy-3β-(4-… to either amphetamine
or CFT challenge by unilateral 6-… time courses after CFT or amphetamine challenges at the …
or CFT challenge by unilateral 6-… time courses after CFT or amphetamine challenges at the …
Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter
JV Ferrer, JA Javitch - … of the National Academy of Sciences, 1998 - National Acad Sciences
… ]2-β-carbomethoxy-3-β-(4-fluorophenyl) tropane (CFT) to the … modification of which affects
CFT binding and to determine … be accessible, we found that CFT binding in X5C, as compared …
CFT binding and to determine … be accessible, we found that CFT binding in X5C, as compared …
[HTML][HTML] Age-associated striatal dopaminergic denervation and falls in community-dwelling subjects
NI Bohnen, MLTM Muller, H Kuwabara… - Journal of …, 2009 - ncbi.nlm.nih.gov
… Regional cerebral [ 11 C]b-CFT binding was determined by graphical analysis of the bolus-…
C]b-CFT, the method that yielded the net uptake constant (K i ) of [ 11 C]b-CFT was shown to …
C]b-CFT, the method that yielded the net uptake constant (K i ) of [ 11 C]b-CFT was shown to …
Application of feedback‐controlled bolus plus infusion (FC‐B/I) method for quantitative PET imaging of dopamine transporters with [18F]β‐CFT‐FE in conscious …
N Harada, H Ohba, T Kakiuchi, H Tsukada - Synapse, 2013 - Wiley Online Library
… We have developed 2β-carbomethoxy-3β-(4-fluorophenyl)-8-(2-[ 18 … β-CFT and [ 11 C]β-CIT-FE
(Harada et al.,2004). In the present study, we applied the FC-B/I method with [ 18 F]β-CFT…
(Harada et al.,2004). In the present study, we applied the FC-B/I method with [ 18 F]β-CFT…
Molecular imaging of the dopamine transporter
A Varrone, C Halldin - Journal of Nuclear Medicine, 2010 - Soc Nuclear Med
… Several 18 F-labeled DAT radioligands have been reported, but only some have been
applied to humans: 18 F-β-CFT, 18 F-2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)…
applied to humans: 18 F-β-CFT, 18 F-2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)…
Uptake inhibitors but not substrates induce protease resistance in extracellular loop two of the dopamine transporter
JD Gaffaney, RA Vaughan - Molecular pharmacology, 2004 - ASPET
… 6B, were obtained with GBR 12909, mazindol, and β-CFT. All of the tested compounds
induced protease resistance between 0.01 and 1 μM, roughly correlating with their affinities for …
induced protease resistance between 0.01 and 1 μM, roughly correlating with their affinities for …