… stress and oxidative damage to the cell. This resulting oxidative stress can damage critical
… Oxidative damage resulting from ROS generation can participate in all stages of the cancer …

… mechanisms through which free radicals can participate in the carcinogenic process. …
Phenol sensitization of DNA to subsequent oxidative damage in 8hydroxyguanine assays. …

… of carcinogenesis using the three general stage designations. Oxidative stress and resulting
oxidative damage … example, the mechanisms of action by which carcinogens induce hepatic …

… In this review, we present the current status of knowledge and evidence on the mechanisms
and involvement of intracellular oxidative stress and DNA damage in human malignancy …

For more than half a century, numerous proposals have been advanced for the mode of
action of carcinogens. This review presents a wide array of evidence that implicates oxidative …

… Thus, oxidative stress is accepted as a critical pathophysiological mechanism in different …
In fact ROS can cause protein, lipid, and DNA damage, and malignant tumors often show …

… It is possible that Ni-induced accumulation of iron may be responsible for increased ROS
formation and DNA damage. Another possible mechanism of Ni-induced carcinogenesis may …

The metal ions carcinogenic to humans are As, … mechanisms was proposed for these metals,
reflecting their diverse chemical properties. The oxidative concept in metal carcinogenesis …

… of that damage to carcinogenesis. Although various target organic molecules and carcinogenic
… for carcinogens and to two elements, nickel and chromium, that are well documented as …

… to the mechanisms of metal carcinogenicity with special emphasis on the emerging hypothesis
of the oxidative nature of metals’ effect on DNA. The carcinogenic transition metals are …