[HTML][HTML] Extracellular glutathione peroxidase GPx3 and its role in cancer

C Chang, BL Worley, R Phaëton, N Hempel - Cancers, 2020 - mdpi.com
… expression levels negatively correlate with increased GPX3 gene methylation in tumor
, it was found that cells immediately adjacent to tumor tissues also display decreased GPx3

Methylation of promoter and expression silencing of GPX3 gene in hepatocellular carcinoma tissue

S Cao, B Yan, Y Lu, G Zhang, J Li, W Zhai… - Clinics and research in …, 2015 - Elsevier
… status of the Gpx3 gene promoter as well as the expression of GPX3 mRNA and protein …
tissues. We also investigated the potential correlation of methylation of the GPX3 gene promoter …

[PDF][PDF] Genetic and epigenetic changes of GPX1 and GPX3 in human clear-cell renal cell carcinoma

EE Rudenko, GV Gerashchenko, YV Lapska… - Вiopolymers and …, 2013 - biopolymers.org.ua
tissues with renal cancer libraries, using SAGE Digital Gene Expression Displayer (DGED)
to find genes with different expression in kidney cancers. Tissue samples. Surgically removed …

[HTML][HTML] GPX3 expression was down-regulated but positively correlated with poor outcome in human cancers

Q Hu, J Chen, W Yang, M Xu, J Zhou, J Tan… - Frontiers in …, 2023 - frontiersin.org
… We further investigated the potential genetic and epigenetic regulation of GPX3 in cancer. …
that GPX3 expression was significantly reduced in tumor tissues compared with normal tissues

[HTML][HTML] Overexpression of GPX3, a potential biomarker for diagnosis and prognosis of breast cancer, inhibits progression of breast cancer cells in vitro

W Lou, B Ding, S Wang, P Fu - Cancer cell international, 2020 - Springer
genes in breast cancer tissues compared with TCGA normal breast … that GPX3 mRNA
expression in breast cancer tissues was much lower than that in adjacent matched normal tissues (…

Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer

S Nirgude, B Choudhary - Biochemical pharmacology, 2021 - Elsevier
GPX3 can be attributed to promoter region hypermethylation of the GPX3 gene, as observed
frequently (70%) in cancers… The tissue sections from lung tumors showed low P-AKT levels, …

Silencing GPX3 expression promotes tumor metastasis in human thyroid cancer

H Zhao, J Li, X Li, C Han, Y Zhang… - Current Protein and …, 2015 - ingentaconnect.com
… is located in 5q23, a region is deleted in prostate cancer [5, 14]. Frequently methylation of
GPX3 gene … Expression of GPX3 in PTC tumor tissues was significantly lower than in adjacent …

[HTML][HTML] Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma

X Qi, KTP Ng, QZ Lian, XB Liu, CX Li, W Geng… - Oncotarget, 2014 - ncbi.nlm.nih.gov
… Besides the down-regulation of GPx3 within tumor tissues, the circulating GPx3 was also
found … Full length of human GPx3 gene was transduced into the hiPSC-MSC cell line [23]. The …

Association between GPX3 promoter methylation and malignant tumors: a meta-analysis

C Zhou, H Hu, Z Zheng, C Chen, Y Li, B Li… - Pathology-Research and …, 2019 - Elsevier
… between GPX3 gene methylation and cancer and to further evaluate its diagnostic value for
… comparing GPX3 methylation data from 696 tumor tissues and 696 paired non-tumor tissues, …

Promoter methylation and clinical significance of GPX3 in esophageal squamous cell carcinoma

Y Lin, Y Zhang, Y Chen, Z Liu - Pathology-Research and Practice, 2019 - Elsevier
… To confirm our results, we compared GPX3 gene expression in normal human esophageal
epithelium and ESCC tissues using the Oncomine database (http://www.oncomine.org ). …