… Based on the overlap of significant gene expression changes with established HAND2 DNA
… putative HAND2-dependent endocardial transcriptional enhancers. We selected five genes …

… These observations indicate that in zebrafish, hand2 regulates cardiac chamber-specific
gene expression and has a more general role in the early morphogenesis and differentiation of …

… be critical for cardiac morphogenesis including, trabeculation… heart and each cell lineage
relies on a finely tuned gene … Hand1 and Hand2 play key roles within the gene regulatory …

… of the myocardial epithelium and that driving myocardial gene expression. Specifically,
we analyzed the role of the myocardial differentiation gene, hand2, in myocardial epithelia …

… component of the Hand2 pathway that mediates cardiac morphogenesis. Although hand2 is
expressed … Here, we provide the first genetic link between Hand2 and a downstream effector …

… utilizing a variety of unique Cre-driver mouse lines, we have revealed some tissue-specific
roles of the Hand2 gene during the development of early cardiac progenitors. More …

… Here, we found that the other Hand gene, Hand2, regulated expansion, trabeculation, and
… of Hand2 during cardiac morphogenesis, we created transgenic mice expressing Hand2 …

… their expression are associated with HAND2 ChIP-seq peaks (… of these genes are associated
with at least one HAND2 ChIP-… of genes functioning in mouse OFT and RV morphogenesis …

… that endocardial Hand2 plays a crucial role in myocardial morphogenesis. Myocardial trabe…
VegfA is the most differentially regulated gene that we observe, while VegfR2, VegfR3, and …

… To better investigate the potential role of these genes in OFT morphogenesis, we
generated specific monoclonal antibodies (in collaboration with Abcam), resulting in a …