… Normal cardiac morphogenesis relies on the precise regulation … of HAND1 and HAND2
deficiency on cardiac lineage commitment … /2 gene regulatory network during heart development. …

… to cause dilated cardiomyopathy (DCM). However, the association of a HAND2 mutation
with … In this research, the coding regions and splicing junction sites of the HAND2 gene were …

… cardiac phenotypes that could be compensated by HAND2, … Hand1;Hand2 genetic interaction
in the second heart field. … critical for OFT morphogenesis with the caveat that HAND2 loss-…

… of cardiac morphogenesis and briefly discuss regulatory genes in the context of an evolving
morphogenetic … of the Hand2 mutant, with under-development of cranial heart segments and …

… Hand2 gene directly causes a human congenital disorder. In this review, we focus on gene
dosage effect of Hand2 in limb, heart… ventricle progenitor cells and morphogenesis of the right …

… of the protein in patients, compared to healthy individuals (Figure 1A), suggesting a role
for the HAND2 gene in the onset/development of the disease. To assess the contribution of …

… Heterozygous sequence variants in the basic helix–loop–helix TF gene heart and neural
crest derivatives expressed 2 (HAND2) have been reported among some patients with CHDs; …

… (A) Genomic structure of zebrafish hand2. The single intron is … (B) No fragment of the hand2
gene can be amplified by PCR … expansion of gene expression reflects the morphogenesis of …

… genes, including the bHLH gene heart and neural crest derivatives expressed transcript 2/hand2
( … gut morphology in hands-off/hanc99 mutants that carry a mutation in the hand2 gene ( …

… of its neighboring gene HAND2 and subsequently on heart … to affect HAND2 expression
and yields no discernable heart … promote HAND2 expression and heart morphogenesis in the …