Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor

N Sivasubramanian, ML Coker, KM Kurrelmeyer… - Circulation, 2001 - Am Heart Assoc
… ) with cardiac restricted overexpression of TNF that develop progressive LV dilation/remodeling
from 4 to 12 weeks of age. During the early phases of LV structural remodeling, there …

Impaired protein quality control during left ventricular remodeling in mice with cardiac restricted overexpression of tumor necrosis factor

J Hartupee, GD Szalai, W Wang, X Ma… - Circulation: Heart …, 2017 - Am Heart Assoc
cardiomyopathy driven by cardiac restricted overexpression … ubiquitin-tagged proteins within
cardiac myocytes related to … from patients with end-stage heart failure. Moreover, there was …

Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging

FG Spinale, GP Escobar, R Mukherjee… - Circulation: Heart …, 2009 - Am Heart Assoc
Left ventricular (LV) remodeling is generically defined as changes in myocardial
Although the LV remodeling process evokes changes within both the cellular and extracellular …

Cardiac-restricted overexpression or deletion of tissue inhibitor of matrix metalloproteinase-4: differential effects on left ventricular structure and function following …

WM Yarbrough, C Baicu, R Mukherjee… - … Physiology-Heart …, 2014 - journals.physiology.org
… with left ventricular (LV) dysfunction and matrix remodeling … the hypothesis that cardiac-specific
overexpression (TIMP-… = 25), whereby indexes of LV remodeling and function such as LV …

Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causes myocardial remodeling and dysfunction in aging mice

JA Zavadzkas, RA Plyler, S Bouges… - … Physiology-Heart …, 2008 - journals.physiology.org
… The matrix metalloproteinases (MMPs) play a pivotal role in adverse left ventricular (LV)
myocardial remodeling. The transmembrane protein extracellular MMP inducer (EMMPRIN) …

Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial …

S Janssens, P Pokreisz, L Schoonjans… - Circulation …, 2004 - Am Heart Assoc
… of cardiac performance and left ventricular (LV) remodeling after … cardiac-restricted
overexpression of endothelial NOS preserves cardiac function and limits deleterious left ventricular

Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction

FG Spinale, R Mukherjee, JA Zavadzkas… - Journal of biological …, 2010 - ASBMB
overexpression (MT1-MMPexp), in a left ventricular (LV) remodeling process such as
myocardial … MI was then induced in mice with cardiac restricted MT1-MMPexp (n = 58) and wild …

MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction

E van Rooij, PA Doevendans, HJGM Crijns… - Circulation …, 2004 - Am Heart Assoc
… MI cardiac remodeling, using a genetic mouse model with mild myocyte-restricted overexpression
of MCIP1, which was previously shown to efficiently antagonize cardiac hypertrophy in …

Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice

T Shiomi, H Tsutsui, H Matsusaka, K Murakami… - Circulation, 2004 - Am Heart Assoc
… On the basis of these findings, it is conceivable to hypothesize that increased myocardial
remodeling. In conclusion, GSHPx overexpression inhibited the development of LV remodeling

Left ventricular remodeling leads to heart failure in mice with cardiac‐specific overexpression of VEGF‐B167: echocardiography and magnetic resonance imaging …

L Lottonen‐Raikaslehto, R Rissanen… - Physiological …, 2017 - Wiley Online Library
… We showed that left ventricular remodeling is already ongoing at the age of 5 months in …
that cardiac‐specific overexpression of VEGF ‐B 167 leads to left ventricular remodeling at early …