[HTML][HTML] Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte

PC Trivedi, JJ Bartlett, A Mercer, L Slade… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… Since DEGs involved in apoptotic processes and cell death were increased in response to
TFEB deficiency in cardiomyocytes, we postulated that TFEB is essential for cardiomyocyte

Anti-apoptosis in nonmyocytes and pro-autophagy in cardiomyocytes: two strategies against postinfarction heart failure through regulation of cell death/degeneration

G Takemura, H Kanamori, H Okada, N Miyazaki… - Heart Failure …, 2018 - Springer
… postinfarction heart failure through control of cell death/degeneration: (1) anti-apoptosis in
granulation tissue noncardiomyocytes; and (2) pro-autophagy in salvaged cardiomyocytes. …

Time course of the apoptotic cascade and effects of caspase inhibitors in adult rat ventricular cardiomyocytes

K Suzuki, S Kostin, V Person, A Elsässer… - … of molecular and cellular …, 2001 - Elsevier
… the effects of several caspase inhibitors on apoptosis, since their efficiency to prevent cell
death and the ultimate fate Identification of apoptosis and necrosis of treated cells are still …

Mechanisms of disease: apoptosis in heart failure—seeing hope in death

J Narula, N Haider, E Arbustini… - Nature clinical practice …, 2006 - nature.com
… Since the loss of cardiomyocytes in failing or cardiomyopathic hearts is gradual and is not
… histomorphological deformity, apoptosis seems to be a logical mechanism of cell death. If …

[HTML][HTML] Underlying the mechanisms of doxorubicin-induced acute cardiotoxicity: oxidative stress and cell death

CY Kong, Z Guo, P Song, X Zhang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
cell death pathways induced by DOX. Hence, we attempt to explain the cellular mechanisms
of oxidative stress and cell death … Interestingly, p53 mediated cardiomyocyte apoptosis and …

Doxorubicin‐induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy

FS Carvalho, A Burgeiro, R Garcia… - Medicinal research …, 2014 - Wiley Online Library
… treatment can result in cell death.139, 140 In fact, a rapidly expanding body of evidence
supports the concept that both endothelial cell and cardiomyocyte apoptosis and necrosis are …

Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways

EJ Anderson, E Rodriguez… - American Journal …, 2011 - journals.physiology.org
cardiomyocyte numbers are two prominent factors that lead to heart failure in experimental
models. Signals that mediate cardiomyocyte cell death … intrinsic apoptosis pathway mediator …

Death by design: programmed cell death in cardiovascular biology and disease

WR MacLellan, MD Schneider - Circulation research, 1997 - Am Heart Assoc
Cardiac myocytes are known to express functionally active receptors of both subtypes.
TNF-α−induced programmed cell death … ligands, suggesting that cardiac myocyte cell death was …

Don't lose heart‐therapeutic value of apoptosis prevention in the treatment of cardiovascular disease

JLV Reeve, AM Duffy, T O'Brien… - Journal of cellular and …, 2005 - Wiley Online Library
… of several cardiovascular diseases. Thus, inhibition of cardiomyocyte apoptosis may represent
Apoptosis is not the only mode of cell death in the heart and it is not clear how much apop…

Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy

C Putinski, M Abdul-Ghani, R Stiles… - Proceedings of the …, 2013 - National Acad Sciences
… Here, we demonstrate that agonist-induced cardiomyocyte hypertrophy is associated with
… mitochondrial cell death pathway as a central conduit for adrenergic-induced cardiomyocyte