[HTML][HTML] Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte
… Since DEGs involved in apoptotic processes and cell death were increased in response to
TFEB deficiency in cardiomyocytes, we postulated that TFEB is essential for cardiomyocyte …
TFEB deficiency in cardiomyocytes, we postulated that TFEB is essential for cardiomyocyte …
Anti-apoptosis in nonmyocytes and pro-autophagy in cardiomyocytes: two strategies against postinfarction heart failure through regulation of cell death/degeneration
G Takemura, H Kanamori, H Okada, N Miyazaki… - Heart Failure …, 2018 - Springer
… postinfarction heart failure through control of cell death/degeneration: (1) anti-apoptosis in
granulation tissue noncardiomyocytes; and (2) pro-autophagy in salvaged cardiomyocytes. …
granulation tissue noncardiomyocytes; and (2) pro-autophagy in salvaged cardiomyocytes. …
Time course of the apoptotic cascade and effects of caspase inhibitors in adult rat ventricular cardiomyocytes
K Suzuki, S Kostin, V Person, A Elsässer… - … of molecular and cellular …, 2001 - Elsevier
… the effects of several caspase inhibitors on apoptosis, since their efficiency to prevent cell
death and the ultimate fate Identification of apoptosis and necrosis of treated cells are still …
death and the ultimate fate Identification of apoptosis and necrosis of treated cells are still …
Mechanisms of disease: apoptosis in heart failure—seeing hope in death
J Narula, N Haider, E Arbustini… - Nature clinical practice …, 2006 - nature.com
… Since the loss of cardiomyocytes in failing or cardiomyopathic hearts is gradual and is not
… histomorphological deformity, apoptosis seems to be a logical mechanism of cell death. If …
… histomorphological deformity, apoptosis seems to be a logical mechanism of cell death. If …
[HTML][HTML] Underlying the mechanisms of doxorubicin-induced acute cardiotoxicity: oxidative stress and cell death
CY Kong, Z Guo, P Song, X Zhang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
… cell death pathways induced by DOX. Hence, we attempt to explain the cellular mechanisms
of oxidative stress and cell death … Interestingly, p53 mediated cardiomyocyte apoptosis and …
of oxidative stress and cell death … Interestingly, p53 mediated cardiomyocyte apoptosis and …
Doxorubicin‐induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy
FS Carvalho, A Burgeiro, R Garcia… - Medicinal research …, 2014 - Wiley Online Library
… treatment can result in cell death.139, 140 In fact, a rapidly expanding body of evidence
supports the concept that both endothelial cell and cardiomyocyte apoptosis and necrosis are …
supports the concept that both endothelial cell and cardiomyocyte apoptosis and necrosis are …
Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways
EJ Anderson, E Rodriguez… - American Journal …, 2011 - journals.physiology.org
… cardiomyocyte numbers are two prominent factors that lead to heart failure in experimental
models. Signals that mediate cardiomyocyte cell death … intrinsic apoptosis pathway mediator …
models. Signals that mediate cardiomyocyte cell death … intrinsic apoptosis pathway mediator …
Death by design: programmed cell death in cardiovascular biology and disease
WR MacLellan, MD Schneider - Circulation research, 1997 - Am Heart Assoc
… Cardiac myocytes are known to express functionally active receptors of both subtypes.
TNF-α−induced programmed cell death … ligands, suggesting that cardiac myocyte cell death was …
TNF-α−induced programmed cell death … ligands, suggesting that cardiac myocyte cell death was …
Don't lose heart‐therapeutic value of apoptosis prevention in the treatment of cardiovascular disease
JLV Reeve, AM Duffy, T O'Brien… - Journal of cellular and …, 2005 - Wiley Online Library
… of several cardiovascular diseases. Thus, inhibition of cardiomyocyte apoptosis may represent
… Apoptosis is not the only mode of cell death in the heart and it is not clear how much apop…
… Apoptosis is not the only mode of cell death in the heart and it is not clear how much apop…
Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy
C Putinski, M Abdul-Ghani, R Stiles… - Proceedings of the …, 2013 - National Acad Sciences
… Here, we demonstrate that agonist-induced cardiomyocyte hypertrophy is associated with
… mitochondrial cell death pathway as a central conduit for adrenergic-induced cardiomyocyte …
… mitochondrial cell death pathway as a central conduit for adrenergic-induced cardiomyocyte …