mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope
MS Kapiloff, N Jackson, N Airhart - Journal of cell science, 2001 - journals.biologists.com
… the nuclear envelope of differentiated cardiac myocytes. Here we present data that the mAKAP
signaling complex also includes nuclear envelope-… to the nuclear envelope, whereas the …
signaling complex also includes nuclear envelope-… to the nuclear envelope, whereas the …
Genetic and ultrastructural studies in dilated cardiomyopathy patients: a large deletion in the lamin A/C gene is associated with cardiomyocyte nuclear envelope …
P Gupta, ZT Bilinska, N Sylvius, E Boudreau… - Basic research in …, 2010 - Springer
… patient samples for (a) cardiomyocyte nuclear abnormalities and (b) … nuclear envelope
architecture. Among the 25 heart samples investigated, we identified major cardiomyocyte nuclear …
architecture. Among the 25 heart samples investigated, we identified major cardiomyocyte nuclear …
An integrated mechanism of cardiomyocyte nuclear Ca2+ signaling
… Ca 2 + signals by activation of plasma membrane receptors relies on the strategic localization
of inositol trisphosphate receptors at the nuclear envelope. There, they mediate Ca 2 + …
of inositol trisphosphate receptors at the nuclear envelope. There, they mediate Ca 2 + …
Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling
… distribution of PLB and tested whether a pool of PLB exists in the nuclear envelope (NE)
that might regulate perinuclear/nuclear Ca 2 + (nCa 2 + ) handling in cardiomyocytes (CMs). …
that might regulate perinuclear/nuclear Ca 2 + (nCa 2 + ) handling in cardiomyocytes (CMs). …
Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope
M Wallace, H Zahr, S Perati, CD Morsink… - Molecular biology of …, 2023 - Am Soc Cell Biol
… the nuclear envelope proteins Lamins A and C, which comprise a major part of the nuclear
lamina, provide mechanical support to the nucleus, and … with cardiomyocyte nuclear envelope …
lamina, provide mechanical support to the nucleus, and … with cardiomyocyte nuclear envelope …
The nuclear envelope: LINCing tissue mechanics to genome regulation in cardiac and skeletal muscle
R Piccus, D Brayson - Biology letters, 2020 - royalsocietypublishing.org
… In ventricular cardiomyocytes, IP 3 Rs are known to generate a nuclear Ca 2+ signal
responsible for transcriptional changes that regulate cardiac hypertrophy [64]. Subsequently, …
responsible for transcriptional changes that regulate cardiac hypertrophy [64]. Subsequently, …
Role of nuclear Lamin A/C in cardiomyocyte functions
… Lamin A/C is a structural protein of the nuclear envelope (NE… role of this protein in the
cardiomyocytes function. Mutations in … of the Lamin A/C in cardiomyocytes function is a key area of …
cardiomyocytes function. Mutations in … of the Lamin A/C in cardiomyocytes function is a key area of …
Structural adaptation of the nuclear pore complex in stem cell–derived cardiomyocytes
C Perez-Terzic, A Behfar, A Méry… - Circulation …, 2003 - Am Heart Assoc
… In contrast, NUP98, a nucleoporin dispensable for cell viability and growth, 20 was apparently
lower in the nuclear envelope of stem cell–derived cardiomyocytes compared with heart …
lower in the nuclear envelope of stem cell–derived cardiomyocytes compared with heart …
Nuclear Ca2+ regulates cardiomyocyte function
S Guatimosim, MJ Amaya, MT Guerra, CJ Aguiar… - Cell calcium, 2008 - Elsevier
… nuclear envelope has been observed throughout the cytosol of ventricular cardiomyocytes
[7]. … The nucleoplasmic reticulum is a nuclear Ca 2+ store organelle continuous with the endo/…
[7]. … The nucleoplasmic reticulum is a nuclear Ca 2+ store organelle continuous with the endo/…
Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells
… Moreover, we demonstrate that Cx43 forms functional channels at the nuclear envelope,
also in cardiomyocytes, and that Cx43 impacts the gene expression landscape of cultured cells. …
also in cardiomyocytes, and that Cx43 impacts the gene expression landscape of cultured cells. …
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