Role of tachykinin NK1, NK2 and NK3 receptors in the modulation of visceral hypersensitivity in the rat

GA Gaudreau, V Plourde - Neuroscience letters, 2003 - Elsevier
Tachykinins are known to be … effect of spinal administration of tachykinin receptor antagonists
in the mediation of visceral hypersensitivity. Intrathecal administration of the NK 1 receptor

Substance P and related tachykinins

NMJ Rupniak, MS Kramer - Neuropharmacology The fifth …, 2002 - books.google.com
… Because the substance P-preferring NK, receptor is the predominant tachykinin receptor
duces a range of fear-related behaviors and defensive cardiovascular changes in animals (78-…

New challenges in the study of the mammalian tachykinins

NM Page - Peptides, 2005 - Elsevier
tachykinin receptors are identified with certainty. The question remains – do more tachykinin
receptors … smooth muscle contraction, emotional behaviour, vasodilation, pain transmission, …

Neurokinin1 Receptor Antagonists as Potential Antidepressants

SC Stout, MJ Owens, CB Nemeroff - Annual review of …, 2001 - annualreviews.org
… further that tachykinin receptor activation can exert multiple behavioral effects depending on
… In a related study, ICV NK 1 , but not NK 2 receptor blockade, reduced the cardiovascular

Tachykinin-1 receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-κB via a Gq-dependent pathway

R Williams, X Zou, GW Hoyle - American Journal of …, 2007 - journals.physiology.org
… in mediating proinflammatory effects in the lung. Three tachykinin receptors have been …
This behavior of Tacr1 has been observed previously and is thought to result from difficulty …

The tachykinin NK-1 receptor antagonist, RP-67580, infused into the ventral tegmental area prevents stress-induced analgesia in the formalin test

N Altier, J Stewart - Physiology & behavior, 1999 - Elsevier
… SP receptors in … effect of blocking tachykinin NK-l receptors in the VTA on footshock
stress-induced analgesia in the formalin test. Intra-VTA infusions of the novel tachykinin NK-l …

Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat

P Picard, S Boucher, D Regoli, BD Gitter… - European journal of …, 1993 - Elsevier
… no significant effect on the decrease in reaction time or behavioral responses … effect of
CP-96,345 on the nociceptive responses to [Sar9,Met(O2)11]Sp is due to systemic cardiovascular

Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors

H Satake, T Kawada - Current drug targets, 2006 - ingentaconnect.com
… vasodilatory effects [1]. This study was the origin of a long history of research on tachykinins
(… On the other hand, SP1-7 was shown to inhibit opiate tolerance and withdrawal behavior in …

Microinjection of the tachykinin neuropeptide K into the ventromedial hypothalamus disrupts the hormonal onset of maternal behavior in female rats

TP Sheehan, M Numan - Journal of neuroendocrinology, 1997 - Wiley Online Library
… of behavioral testing does not disrupt maternal behavior in rats that warrant consideration,
such as a reduction in tachykinin receptor … the effects of estrogen on tachykinin mRNA (41, 42), …

Substance P targets sympathetic control neurons in the paraventricular nucleus

MD Womack, R Morris, TC Gent… - Circulation …, 2007 - Am Heart Assoc
… (tachykinins) play a major role in cardiovascular control and the … heart rate resulting from
psychological stress of conscious rats… highly selective tachykinin receptor ligands. NK2 and NK3 …