… In this review, we discuss the cardiovascular effects of adiponectin, specifically its anti-… the
cardiovascular system. We next examine the interpretation of circulating adiponectin levels as …

… is simply a marker of glucose homeostasis, with no direct favorable effect on the risk of type
2 diabetes and cardiovascular disease. But even more unforeseen were data addressing the …

… factors are unlikely to explain the “adiponectin paradox”. Based on recent insights, an
alternative potential explanation for the adiponectin paradox is proposed in the current manuscript. …

… The basis for the adiponectin paradox remains poorly defined, but an improved understanding
of its features is emerging. As relates to aging, which is associated with longitudinal …

… a clinical biomarker in cardiovascular disease, providing … adiponectin in cardiovascular
disease. We systematically present the mechanisms by which adiponectin affects cardiovascular …

… of adiponectin signal lower diabetes risk, they simultaneously signal higher all-cause and
cardiovascular disease (CVD) mortality. How can these apparent paradoxical observations be …

… Over a mean follow-up time of 6.2 years, 222 individuals died, and 52 deaths (23.4%) were
by cardiovascular disease. After adjusting confounding factors, elevated baseline serum …

… adiponectin and diminished MI risk over a 6-year follow-up in subjects with no prior cardiovascular
disease… had a similar relationship of adiponectin levels to cardiovascular risk, and this …

… and cardiovascular disease. … paradoxical effects of adiponectin in cardiovascular mortality,
we turn our attention to the source of circulating adiponectin, in the context of cardiovascular …

… Our results point strongly to a paradoxical association between high adiponectin levels and
… , has made adiponectin a promising therapeutic target for tackling cardiovascular disease (…