Mitochondrial aldehyde dehydrogenase and cardiac diseases

CH Chen, L Sun, D Mochly-Rosen - Cardiovascular research, 2010 - academic.oup.com
… Many other reactive and cytotoxic aldehydes have been shown to be associated with other
diseases. Of particular interest to cardiovascular diseases are reactive aldehydes such as 4-…

The role of aldehyde dehydrogenase 2 in cardiovascular disease

J Zhang, Y Guo, X Zhao, J Pang, C Pan… - Nature Reviews …, 2023 - nature.com
… ALDH2 rs671, a polymorphism in the gene encoding aldehyde dehydrogenase 2 (ALDH2),
accelerates the development of coronary artery disease via its non-enzymatic and enzymatic …

The potential of aldehyde dehydrogenase 2 as a therapeutic target in cardiovascular disease

T Münzel, A Daiber - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
… The enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) is well known from the field
of alcoholism research. The enzyme accounts for the removal of toxic acetaldehyde upon …

Aldehyde dehydrogenase-2 roles in ischemic cardiovascular disease

X Liu, A Sun - Current Drug Targets, 2017 - ingentaconnect.com
cardiovascular disease and the underlying mechanisms. Since ALDH2 is emerging as a
potential therapeutic target of cardiac … inhibition in ischemic cardiovascular disease. In particular…

Aldehyde metabolism in the cardiovascular system

D Conklin, R Prough, A Bhatanagar - Molecular BioSystems, 2007 - pubs.rsc.org
… of fatty aldehydes . The ALDH3A2 gene encodes the fatty aldehyde dehydrogenase (FALDH; …
the causative role of aldehydes in cardiovascular disease induction and progression. To-…

Role of reactive aldehyde in cardiovascular diseases

K Uchida - Free radical biology and medicine, 2000 - Elsevier
… and atherosclerosis may partly explain the role of these aldehydes in the pathogenesis of
cardiovascular diseases. Aldehyde-induced oxidative stress and oxidative stress response …

ALDH2 and cardiovascular disease

CH Chen, JCB Ferreira, D Mochly-Rosen - Aldehyde Dehydrogenases …, 2019 - Springer
… of other endogenous and exogenous aldehydes, especially lipid peroxidation-derived
reactive aldehyde under oxidative stress. Many cardiovascular diseases are associated with …

[PDF][PDF] … of human aldehyde dehydrogenase bright cells in therapy of cardiovascular diseases: expression analysis of angiogenic factors and aldehyde dehydrogenase …

HS White, L Smith, T Gentry, AE Balber - J Stem Cell Res Ther S, 2011 - m.23michael.com
… Cell populations with high aldehyde dehydrogenase (ALDH) … being investigated to treat
cardiovascular diseases [18]. … high ALDH activity and four of the 19 human ALDH isozymes …

[HTML][HTML] Association of aldehyde exposure with cardiovascular disease

S Liao, J Zhang, S Shi, D Gong, X Lu, I Cheang… - Ecotoxicology and …, 2020 - Elsevier
… was to determine whether aldehyde exposure is associated with the prevalence of
cardiovascular disease (CVD). We analyzed associations between aldehydes and CVD using data …

[HTML][HTML] Changes in cardiac mitochondrial aldehyde dehydrogenase 2 activity in relation to oxidative stress and inflammatory injury in diabetic rats

HJ Wang, PF Kang, WJ Wu… - Molecular …, 2013 - spandidos-publications.com
… The aim of the present study was to determine the changes in mitochondrial aldehyde
dehydrogenase 2 (ALDH2) activity in relation to oxidative stress and inflammatory injury in …