… Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator
of oxygen homeostasis in all metazoan species. HIF-1 … mechanisms, HIF-1 plays a critical …

… importance of HIF-1 cellular hypoxia and the pathophysiology of cardiovascular disease,
and we offer insight into potential clinical therapies involving the modulation of HIF-1 pathways. …

… Small molecule HIF-PH inhibitors are currently used to activate HIF-α signaling and to … of
the HIF-α signaling pathway in cardiovascular diseases. This will include the roles of HIF-1α in …

… as HIF inhibitors … cardiovascular diseases. The purpose of this review is to summarize the
recent advances on HIFs in the pathogenesis and pathophysiology of cardiovascular diseases …

… General involvement of hypoxiainducible factor 1 in transcriptional response to hypoxia.
Proc Natl Acad Sci US A. 1993; 90: 4304-4308 10) Maxwell PH, Wiesener MS, Chang GW, …

… Here we review the molecular regulation of HIF-1 in cardiovascular diseases, intended to
improve therapeutic approaches for clinical diagnoses. Better knowledge of the oxygen …

… induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription ofgenes encoding
vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression…

… as anaemia, lung diseases and sleep apnoea, which can all reduce oxygen delivery to
the heart [1,2]. This review will focus on cardiovascular diseases that directly change oxygen …

… HypoxamiR deregulation, functions, and transcriptional regulation are summarized in Table
1. Hypoxia-Inducible Factor 1: An miRNA-Mediated Modulator Hypoxia-inducible factor 1 …

… Structural and functional analysis of hypoxia inducible factor 1 (HIF-1) has been studied
in great depth (Semenza et al. Citation1997). Two subunits have been identified by protein …