… role of HDACs in cardiovascular diseases, the PTMs of the HDACs themselves as well as …
) the roles of each HDAC in specific cardiovascular diseases and 2) the PTM of HDACs, 3) and …

… Histone deacetylases (HDACs) regulate gene transcription by catalyzing the … HDAC inhibitors
may prove to be powerful therapeutic agents for the treatment of cardiovascular diseases, …

… of class I HDACs was assessed in a preclinical model of pulmonary hypertension, where
it was determined that selective class I histone deacetylase inhibition suppresses hypoxia-…

… cardiovascular disease has also been addressed [13,14]. In this review, the involvement of
HDACs in the development of cardiovascular diseases (… the potential of HDAC inhibitors as a …

… new targets for therapy in cardiovascular disease. Epigenetic processes are reversible by …
of HATs and histone deacetylases (HDACs) and of HMTs and histone demethylases, and are …

… Conversely, histone deacetylation alters the electrostatic properties of chromatin in a
manner that favours the repression of gene transcription 7 . Lysine acetylation additionally …

Heart failure is a major public health problem in western society. Recently, agents that
inhibit histone deacetylase (HDAC) enzymes were developed and approved by the FDA as …

… assess their efficacy and safety for cardiovascular disease prevention and treatment; treatment
of venous thrombosis, Alzheimer's disease, autoimmune and proinflammatory conditions, …

… histone deacetylases in cardiometabolic disease is expected to provide insight into disease
… The link between HDACs and cardiovascular disease is less well developed compared with …

… Atherosclerosis is the most common underlying cause of cardiovascular diseases, such as
myocardial infarction, hypertension and stroke, and is a slowly progressing disease in which …