… matrix degradation products potentiate NF-κB-dependent signaling pathways, further providing
inflammatory mediators that accelerate cartilage destruction. Because the roles of NF-κB …

… MMPs that induce cartilage degradation, and the proinflammatory cytokines (IL-1β and tumor
necrosis factor α,TNF-α) that induce them. Further, continued NF-κB activation results in the …

… To further determine the functions of YAP in protecting cartilage degradation during OA
progression, … that YAP is necessary and sufficient to protect cartilage degradation in OA condition. …

… After IκB degradation, NF-κB hetero-dimers are free to translocate into the nucleus and trigger
… cartilage undergoes during OA development, lead to a constitutive expression of NF-κB …

… Effects of Ononin on IL-1β-induced cartilage degradation and overexpression of MMP-13 in
… assess cartilage tissue metabolism, and MMP-13 is the major cartilage degradation enzyme …

… condylar cartilage degradation and cartilage extracellular matrix loss during TMJOA
progression. On one hand, elevation of catabolic mediators is responsible for cartilage degradation …

Osteoarthritis (OA) is a common joint disease in the elderly population. Its development has
been reported to be associated with cartilage degradation and inflammatory responses. …

… IL-1β-induced NF-κB activation via inhibition of IκB-α … and degradation, p65 nuclear
translocation and NF-κB-regulated gene products involved in inflammation and cartilage degradation …

… We used an ex vivo culture model of cartilage explants from nine 4-week-old rats to evaluate
effect of UA on cartilage degradation. The cartilage explants were treated with UA (15 μM) …

Osteoarthritis (OA) is an urgent public health problem; however, the underlying causal
mechanisms remain unclear, especially in terms of inflammatory mediators in cartilage …