Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease

SK Pierson, S Shenoy, AB Oromendia… - Blood …, 2021 - ashpublications.org
Idiopathic multicentric Castleman disease (iMCD) is a poorly understood hematologic disorder
involving cytokine-induced polyclonal lymphoproliferation, systemic inflammation, and …

[HTML][HTML] Castleman disease

A Carbone, M Borok, B Damania, A Gloghini… - … Reviews Disease …, 2021 - nature.com
Castleman disease (CD), a heterogeneous group of disorders that share morphological
features, is divided into unicentric CD and multicentric CD (MCD) according to the clinical …

A novel predictive model for idiopathic multicentric Castleman disease: the international Castleman disease consortium study

L Yu, M Shi, Q Cai, P Strati, F Hagemeister… - The …, 2020 - academic.oup.com
… The predictive value was validated in an independent set of 197 patients with iMCD from
The International Castleman Disease Consortium. The proposed novel model is valuable for …

[HTML][HTML] CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease

SK Pierson, L Katz, R Williams, M Mumau… - Nature …, 2022 - nature.com
… We discover that CXCL13 is one of the most upregulated proteins in iMCD patient sera
relative to healthy donors. We also identify and validate CXCL13 as an early indicator of …

Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease

DC Fajgenbaum - Blood, The Journal of the American Society …, 2018 - ashpublications.org
Castleman disease (CD) describes a heterogeneous group of hematologic disorders that
share characteristic lymph node histopathology. Patients of all ages present with either a …

[HTML][HTML] Characterizing Mortality Associated with Idiopathic Multicentric Castleman Disease

SK Pierson, K Kanhai, A Bagg, D Alapat, MS Lim… - Blood, 2021 - Elsevier
… multicentric Castleman disease with JAK1/2 inhibition’ and ’Discovery and validation
of a novel subgroup and therapeutic target in idiopathic multi- centric Castleman disease 

The disease course of Castleman disease patients with fatal outcomes in the ACCELERATE registry

DC Fajgenbaum, SK Pierson, K Kanhai… - British journal of …, 2022 - Wiley Online Library
… idiopathic multicentric Castleman disease with JAK1/2 inhibition” and “Discovery and validation
of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease.” …

Transcriptome and unique cytokine microenvironment of Castleman disease

A Wing, J Xu, W Meng, AM Rosenfeld, EY Li… - Modern …, 2022 - nature.com
Castleman disease (CD) represents a group of rare, heterogeneous and poorly understood
disorders that share characteristic histopathological features. Unicentric CD (UCD) typically …

[HTML][HTML] Recurrent PDGFRB mutations in unicentric Castleman disease

Z Li, X Lan, C Li, Y Zhang, Y Wang, W Xue, L Lu, M Jin… - Leukemia, 2019 - nature.com
… Asn666Ser were validated by targeted deep … Castleman Disease Collaborative Network
(CDCN) for their excellent work on accelerating researches and treatment for Castleman disease

Clinical spectrum of Castleman disease–associated neuropathy

E Naddaf, A Dispenzieri, J Mandrekar… - Neurology, 2016 - AAN Enterprises
Castleman disease from our prior study. Therefore, 3 groups of patients were compared:
those with Castleman disease … For further validation, we analyzed the correlation between the …