Catalase expression impairs oxidative stress-mediated signalling in Trypanosoma cruzi

ACG Freire, CL Alves, GR Goes, BC Resende… - Parasitology, 2017 - cambridge.org
cruzi cell line expressing catalase from Escherichia coli, and investigated how this … We
found that catalase heterologous expression in T. cruzi affects both the oxidative stress-induced …

Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide

JK Finzi, CWM Chiavegatto, KF Corat, JA Lopez… - Molecular and …, 2004 - Elsevier
… As an intracellular parasite, Trypanosoma cruzi is exposed to reactive … In this work, the
involvement of TcCPX in T. … Control of gene expression at the transcriptional level is an important …

Catalase compromises the development of the insect and mammalian stages of Trypanosoma brucei

E Horáková, D Faktorová, N Kraeva, B Kaur… - The FEBS …, 2020 - Wiley Online Library
… trypanosomatid, Trypanosoma cruzi, the … catalase expression on parasite’s fitness [31].
This study aimed to investigate the impact of catalase expression in an extracellular parasite T. …

[HTML][HTML] The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress …

FB Nogueira, JFA Rodrigues, MMS Correa… - Memórias do Instituto …, 2012 - SciELO Brasil
… in 11 strains of Trypanosoma cruzi that are sensitive or resistant to benznidazole (BZ).
Bioinformatic analysis revealed the presence of two complete copies of the T. cruzi APX (TcAPX) …

Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi

A Boveris, H Sies, EE Martino, R Docampo… - Biochemical …, 1980 - portlandpress.com
… -metabolizing enzymes in T. cruzi, superoxide dismutase, catalase and ascorbate peroxidase
were … Enzyme activities are expressed as in Table 1, exceptsuperoxide dismutase. One …

ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart

CN Paiva, E Medei, MT Bozza - PLoS Pathogens, 2018 - journals.plos.org
… response to infection with Trypanosoma cruzi inflicts oxidative damage … The antioxidant
enzymes expressed by T. … CAT-PEG, catalase conjugated to polyethylene glycol to permeate the …

[HTML][HTML] New perspectives for hydrogen peroxide in the amastigogenesis of Trypanosoma cruzi in vitro

JIO Paula, J da Silva Pinto, A Rossini… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… Peg-Catalase was the only effective antioxidant against the … -4 glycoprotein expression
showed that Peg-Catalase totally … Therefore, we investigated whether Trypanosoma cruzi

Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole

NJ Temperton, SR Wilkinson, DJ Meyer… - Molecular and …, 1998 - Elsevier
… superoxide dismutase (SOD) we transfected epimastigotes with an expression vector containing
a … They lack catalase and glutathione peroxidase and H 2 O 2 detoxification has been …

Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi

JA Lopez, TU Carvalho, W de Souza, L Flohé… - Free Radical Biology …, 2000 - Elsevier
Trypanosoma cruzi is supported here by immunohistochemistry. Epimastigotes of T. …
and demonstrated by functional expression of the pertinent gene in E. coli. TXNPx of …

Resveratrol impacts in oxidative stress in liver during Trypanosoma cruzi infection

M Fracasso, AD da Silva, NB Bottari, SG Monteiro… - Microbial …, 2021 - Elsevier
… The infection produced high levels of TBARS, NOx, and ROS levels in liver tissue, suggesting
cellular injury with production of free radicals in animals infected by T. cruzi. RSV positively …