Distribution of salicylate in lens and intraocular fluids and its effect on cataract formation

E Cotlier, YR Sharma, T Niven, M Brescia - The American Journal of …, 1983 - Elsevier
salicylate and aspirin on lens and cataract formation are under investigation. Two major
avenues of research in the diabetic lens include effects of salicylate … by sodium salicylate. These …

Ocular distribution of aspirin and salicylate following systematic administration of aspirin to rabbits

P Valeri, L Romanelli, L De Paolis… - Journal of pharmacy …, 1988 - academic.oup.com
… Abstract-The distribution of aspirin and salicylate 30 min after the intravenous administration
… (1983) Distribution of salicylate in lens and intraocular fluids and effect on cataract formation

Distribution of salicylate in pigmented rabbit ocular tissues after application of a prodrug, sodium monomethyl trisilanol orthohydroxybenzoate: in vivo and ex vivo …

L CHANALET, M ETTAICHE, C BAUDOUIN… - Journal of ocular …, 1995 - liebertpub.com
… brown pigment observed in senile cataracts and aldose reductase (11), inducing sorbitol
accumulation from an excess of glucose in lens and involved in diabetic cataracts. Few studies …

Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined to diabetes

E Cotlier - International ophthalmology, 1981 - Springer
… Considering the small differences in distribution between … salicylates slow down cataract
formation in other populations as well (5). A prospective study of aspirin in cataract formation

Rheumatoid arthritis and cataract surgery: Do salicylates slowdown cataract formation?

E Cotlier - International Ophthalmology, 1980 - Springer
… The information had been collected as a part of an epidemiological study on complications
or cataract surgery (1). The age distribution of each group is shown in Tables 1 and 2. …

… of soluble lens proteins and prevents cyanate-induced phase separation opacities in vitro: a possible mechanism by which aspirin could prevent cataract

M Crompton, KC Rixon, JJ Harding - Experimental eye research, 1985 - Elsevier
… There is some evidence that aspirin is beneficial to cataract patients, so its effect on the …
Distribution of salicylate in lens and intraocular fluids and its effects on cataract formation. …

[HTML][HTML] Topical aspirin provides protection against galactosemic cataract

SK Gupta, S Joshi, R Tandon… - Indian journal of …, 1997 - journals.lww.com
… [ 20 , 21 ] Our kinetic studies confirm that salicylate efficiently crosses the goat cornea and
as much as 65% of the applied drug becomes available over 5 hrs. Our results demonstrate …

Cataract formation and prevention

H Shichi - Expert opinion on investigational drugs, 2004 - Taylor & Francis
… is associated with a recessively inherited cataract in mice [24,25]. Extensively investigated
examples of osmotic cataract are sugar cataract and diabetic cataract in animal models, in …

Aspirin and galactose-induced cataract formation in rats

JD Ribaya-Mercado, SN Gershoff - Nutrition Research, 1987 - Elsevier
… of 100 mg of sodium salicylate per kg of body weight for 21 days (30). Since their rats
weighed 230 g, the rats received daily injections of about 23 mg of sodium salicylate. In our …

Drugs designed to maintain the transparence of the ocular lens

L Chanalet, P Lapalus - Fundamental & clinical pharmacology, 1994 - Wiley Online Library
Distribution of salicylate in lens and intraocular fluids and its effect on cataract formation (Aspirin
Symposium). Am 3 Med 1983;14:83-90 Crabbe JC, Petchey M. The penetration of …