… cofactors like CBP and p300 are believed to function biochemically. In the next several
sections we will review aspects of HATs and histone acetylation to help place them in the context …

… other locus-specific histone acetylation events. CBP/p300 can also be important for transcription,
but the recruitment of CBP/p300 and their associated histone acetylation marks do not …

… deacetylase (HDAC) activity, has strongly linked histone acetylation to transcriptional … In
addition to their ability to acetylate histones, CBP and p300 have also been shown to acetylate …

… CBP/P300 proteins have intrinsic histone acetyltransferase (HAT) activity due to their HAT
domains and, like CBP/p300 associated factor (PCAF), induces the acetylation of histone H3 …

… requires p300, implicating a role for histone acetylation also in p21 gene expression (59, 60).
Our results demonstrated that p300/CBP … Therefore, similar to PAI-1, p300/CBP may act as …

… CBP in vivo include a large number of eRNAs. Using steady-state histone acetyltransferase
(… the HAT domain of CBP—a regulatory motif unique to CBP/p300—allows RNA to stimulate …

… -acetylated nucleosomes, we report the directionality in which the catalytically active p300
multidomain reads/writes histone acetylation … a model in which p300/CBP ensures epigenetic …

… the principal antagonists of P300/CBP by counteracting acetylation turnover kinetics. Finally…
and P300/CBP inhibition. Overall, this study indicates that the steady-state histone acetylation…

… We next investigated how acetylation of histones H3 and H4 by CBP/p300 contributes to
NHEJ. The accessibility of proteins to DNA in vivo is regulated by cooperation between histone …

… Here, we demonstrate that p300/CBP is not only a transcriptional adaptor but also a histone
acetyltransferase. … Therefore, we conclude that p300 per se is a histone acetyltransferase. …