CD4+ CXCR5+ T cells in chronic HCV infection produce less IL-21, yet are efficient at supporting B cell responses

M Spaan, K Kreefft, GN de Graav, WP Brouwer… - Journal of …, 2015 - Elsevier
… patients, we show that CXCR5 + CD4 + T cells from chronic HCV patients are able to
stimulate B cells into IgG and IgM-producing plasmablasts, and no evidence was observed for …

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

R He, S Hou, C Liu, A Zhang, Q Bai, M Han, Y Yang… - Nature, 2016 - nature.com
… E2A has been reported to regulate CXCR5 expression in CD4 + T cells 16,17 . We further
determined whether Cxcr5 expression was directly targeted by the E2A–Id2 axis in CXCR5 + …

[HTML][HTML] Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection

JR Larrubia, S Benito-Martínez, M Calvino… - World journal of …, 2008 - ncbi.nlm.nih.gov
… infect CD4 T cells, thus extending host survival[57,58]. Another study into HCV infection
described … It has been shown that the HCV-E2 protein, after binding to CD81[59], induces CCL5 …

Virus-specific CD4+ T cells have functional and phenotypic characteristics of follicular T-helper cells in patients with acute and chronic HCV infections

B Raziorrouh, K Sacher, RG Tawar, F Emmerich… - Gastroenterology, 2016 - Elsevier
… For the identification of Tfh cells within HCV-specific CD4 T cells, we stained for CXCR5 and
… percentages of CXCR5 expression on virus-specific CD4 T cells compared with bulk CD4 T …

Patients with chronic hepatitis C express a high percentage of CD4+CXCR5+ T follicular helper cells

J Feng, X Hu, H Guo, X Sun, J Wang, L Xu… - Journal of …, 2012 - Springer
infection is unclear. This study examined the possible involvement of CD4 + CXCR5 + T
FH cells in chronic hepatitis C (HCV… 1-positive CD4 + CXCR5 + T FH cells in 39 HCV-infected

Divergent Expression of CXCR5 and CCR5 on CD4+ T Cells and the Paradoxical Accumulation of T Follicular Helper Cells during HIV Infection

J Zaunders, Y Xu, SJ Kent, KK Koelsch… - Frontiers in …, 2017 - frontiersin.org
CD4 T HIV Gag-specific cells in peripheral blood that make IFN-γ. Altogether, CXCR5 + CCR5
CD4 … to operate and expand during HIV-1 infection, but at the same time can contain HIV …

[PDF][PDF] Increased numbers of CD5 CD19 CD1d high IL-10 Bregs, CD4 Foxp3 Tregs, CD4 CXCR5 Foxp3 follicular regulatory T (TFR) cells in CHB or CHC patients

L Wang, J Qiu, L Yu, X Hu, P Zhao, Y Jiang - 2014 - … -medicine.biomedcentral.com
… or hepatitis C virus (HCV) infection remains a serious health problem in the world, particularly
in China. Currently, HBV or HCV infection … Persistent infection with HBV or HCV can cause …

[PDF][PDF] Chemokines in the immunopathogenesis of hepatitis C infection

M Heydtmann, DH Adams - Hepatology, 2009 - Wiley Online Library
HCV infection,15 but it is unclear whether mDC function is impaired.Viral clearance is associated
with a vigorous, multispecific CD4 … B lymphocytes also express CXCR5, and this allows …

[PDF][PDF] … chemokine (C‐X‐C Motif) receptor 5+CD4+ T cells benefit hepatitis B e antigen seroconversion through IL‐21 in patients with chronic hepatitis B virus infection

Y Li, S Ma, L Tang, Y Li, W Wang, X Huang, Q Lai… - …, 2013 - Wiley Online Library
… Exclusion criteria for these studies were coinfection with hepatitis A virus, hepatitis C virus
(HCV)… CXCR5 expressing human central memory CD4 T cells and their relevance for humoral …

[HTML][HTML] CXCL13-mediated recruitment of intrahepatic CXCR5+ CD8+ T cells favors viral control in chronic HBV infection

Y Li, L Tang, L Guo, C Chen, S Gu, Y Zhou, G Ye… - Journal of …, 2020 - Elsevier
… also exist in patients with chronic HBV infection, and that CXCR5 + CD8 + T cells may have
… in supernatants were found in the coculture with CXCR5 + CD4 + T cells, while there were …