… the CD4+ tumor cell line Jurkat. Here we show that CD4+ primary T cells lentivirally transduced
with HCV-core… CD4+ or CD8+ T cells in response to anti-CD3 plus anti-CD28 stimulation. …

… Th1 and Tr1 subtypes of CD4 T cells are induced during infection with HCV, we established
HCV core-specific CD4 T cell lines and clones from a number of HCV-infected donors (table …

… were cultured in the presence of HCV core protein, nonstructural proteins NS3 and NS5,
and recall antigens tetanus toxoid and Candida. Secretion of interferon (IFN- ), tumor necrosis …

… CD4 T cells do indeed play a role in HCV infection, and 2) to examine the possible interactions
between CD4 T cells … in hepatitis C virus corespecific peripheral blood T lymphocytes. J …

… have circulating CD4 + T cells with the ability to recognize HCV core, but these cells respond
to … of IL-2, similar to that found in CD4 + T cells stimulated by DC expressing HCV antigens. …

… Based on our previous observation that HCV core interaction with … of HCV core/gC1qR
interaction on DC function and examine the impact of HCV core treatment of DCs on CD4 + T cell …

… responses and viral persistence in HCV-infected individuals. We postulated that HCV core
protein (HCVc) directly contributes to the expansion of Tregs in HCV-infected patients, and we …

… HCV-specific Th1 cytokine-producing effector CD4 T cells inversely correlate with HCV disease
severity, being greatest in HCV … this study to elicit CD4 T cell responses (core, NS3, and …

… blood CD4 + T reg -cells in patients with chronic hepatitis C and … active HCV core-specific
T reg -cells in patients with chronic hepatitis C, which share their epitopes with conventional T-…

… the late limited to the HCV-C C-terminus. Thus, we demonstrate both T-cell immunogenicity
and T-cell modulation by core of HCV 1b. Immune modulation by HCV core may affect host …