… CD40 and CD40L are important regulators of a variety of humoral and cellular immune
responses [50–52]. Their critical role … in the absence of the CD40L-CD40 interaction [53]. However…

… In view of the critical role of CD40-CD40L interactions in humoral immune responses,
strategies have been developed to either decrease or increase these responses. Blocking anti…

… It is clear that CD40L plays a critical role in controlling B-cell fate during many of the
aforementioned checkpoints in B-cell growth and differentiation. When Th cells are activated by DCs …

… CD40-CD40L interaction is also required for formation of B memory cells and germinal …
through CD40 prevents apoptosis of germinal center B cells. Defective expression of CD40L in …

… The demonstration of the critical role of CD40/CD40L … , is due to a ge netic alteration of the
CD40L [35]. This disease is … The generation of CD40 and CD40L knockout mice revealed a …

… costimulatory signals delivered via the CD40-CD40L pair of molecules. CD40L is a
member of … As activated T cells are thought to play a key role, it is not surprising that CD40-CD40L …

… Armitage RJ, Macduff BM, Spriggs MK, Fanslow WC 1993 Human B cell proliferation and
Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J …

… Cognate interactions between CD40 and CD40L … of CD40 ligation is the switch in
recombination and synthesis of immunoglobulins by B cells 15 (fig 2). The critical role of …

… interactions through the CD40–CD40-ligand (CD40L) pathway might … The present study
evaluated the role of the CD40–CD40L … pointed to a crucial role for CD40–CD40L interactions in …

… CD40/CD40L signal transduction and cellular response The interaction of CD40 with its
cognate ligand CD40L and the key role it … that CD40–CD40L coupling plays a crucial role in …