Differential CD40/CD40L expression results in counteracting antitumor immune responses

G Murugaiyan, R Agrawal, GC Mishra… - The Journal of …, 2007 - journals.aai.org
… an immune response. The nature of antitumor immune response is a function of the extent of
CD40 … have important implications for the immunotherapy of infectious diseases and cancer. …

Mechanistic basis of co-stimulatory CD40-CD40L ligation mediated regulation of immune responses in cancer and autoimmune disorders

TC Dakal, B Dhabhai, D Agarwal, R Gupta, G Nagda… - Immunobiology, 2020 - Elsevier
… of the CD40 with a deregulated amount of CD40 ligand has been implicated … CD40-CD40L
mediated regulation of immune response and involvement in the pathophysiology of cancer

Molecular mechanism and function of CD40/CD40L engagement in the immune system

R Elgueta, MJ Benson, VC De Vries… - Immunological …, 2009 - Wiley Online Library
immune response, abrogation of the CD40/CD40L pathway has no impact on the thymus-independent
(TI) antibody response… anti-tumor immunity and CD40 can be a cancer-associated …

Role for CD40CD40 ligand interactions in the immune response to solid tumours

AB Alexandroff, AM Jackson, T Paterson, JL Haley… - Molecular …, 2000 - Elsevier
immune cells. In the current study we examined the role of CD40-mediated interactions in
immune responses … Finally, the presence of CD40 on the surface of carcinoma lines was found …

[HTML][HTML] CD40/CD40 ligand interactions in immune responses and pulmonary immunity

T Kawabe, M Matsushima, N Hashimoto… - Nagoya journal of …, 2011 - ncbi.nlm.nih.gov
… on the role of the CD40L/CD40 costimulatory system in the context of … of the CD40L/CD40
system can be found in the literature. … We established CD40L-expressing lung cancer cells by …

The role of the CD40 pathway in the pathogenesis and treatment of cancer

AG Eliopoulos, LS Young - Current opinion in pharmacology, 2004 - Elsevier
… Indeed, the activation of CD40 by CD40 ligand (CD40L) … immune responses, promoting
their differentiation into immunoglobulin-producing plasma cells. In addition, the CD40-CD40L

Multiple effects of CD40CD40L axis in immunity against infection and cancer

A Ara, KA Ahmed, J Xiang - ImmunoTargets and therapy, 2018 - Taylor & Francis
… Citation15 CD40CD40L is a pair of costimulatory … immune responses. There is a plethora
of reports that suggest the importance of CD40CD40L interaction in immune responses

Use of CD40L immunoconjugates to overcome the defective immune response to vaccines for infections and cancer in the aged

YC Tang, M Thoman, PJ Linton… - Cancer Immunology …, 2009 - Springer
… to the target antigen, as the carboxylterminus of CD40L is the end of CD40L, which
engages the CD40 receptor. Since all of the sequences necessary for the assembly of the …

The CD40/CD40L system: a new therapeutic target for disease

B Zhang, T Wu, M Chen, Y Zhou, D Yi, R Guo - Immunology letters, 2013 - Elsevier
… as atherosclerosis, diabetes mellitus, immunological rejection and cancer. … CD40/CD40L
system as applied to a range of cardiovascular diseases, immune system disorders and cancers

CD40 ligand induces an antileukemia immune response in vivo

D Dilloo, M Brown, M Roskrow, W Zhong… - Blood, The Journal …, 1997 - ashpublications.org
CD40L could enhance an antileukemia immune response using a CD40 + murine lymphoblastic
(A20) leukemia and a CD40 − … presence of CD40L induced an immune response active …