… pro-B cells to develop into T cells (83). However, Bcl11b-deficient T cells and T-committed …
not reciprocally adopt the B-cell fate but appear to develop chiefly into NK cells (82). Bcl11b-…

… CD8 T cell response, and memory CD8 T cells were isolated at least 40 days pi Naı̈ve P14
CD8 T cells … -γ or cytotoxic molecules, whereas d8 effector cells were CD44 hi , CD62L lo , …

… regulation of terminal effector and memory cell fate decisions, it seems likely that this pathway
may also directly influences the epigenetic state of CD8 + T cells. How these signals are …

… stochastically give rise to progenies comprising either terminal T EFF, or T MEM cell fates,
35 it is likely that the initial divergence in gene expression among first-generation daughter …

… proliferate, they continuously generate a population of CD8 T cells that are nonfunctional and
… to identify the CD8 T cells that are destined to die within a memory CD8 T-cell population. …

… T cell fate decisions 54,55 , are prone to give rise to KLRG1 + terminal effector T cell-like cells,
… BLIMP1 in determining T RM cell fate in the circulating T cell pool, we note that circulating …

… To track individual T cells in a system in which differences in T cell receptor (TCR) affinity do
not influence cell fate, we generated naïve TCR-transgenic OT-I T cells [which recognize the …

… CD4 or CD8 T cells. Cells expressing less Notch adopt the primary CD4 cell fate, normally in
… Development of CD8 T cells generally requires MHC class I ligation, and Notch expression …

… of T-bet expressed upon reactivation and preexisting memory CD8 T cell number (ie, primary
memory CD8 T cell … Compared with naive cells, memory CD8 T cells were predisposed …

… An important question is how differentiating CD8 + T cells 'choose' among effector cell fates.
This 'choice' may be affected by asymmetric segregation of fate-determining factors 16 . It …