CD8 T cell quiescence revisited

SE Hamilton, SC Jameson - Trends in immunology, 2012 - cell.com
… The colors of the naïve T cells correlate with CD5 expression levels on mouse naïve CD8
T cells – with CD5 low cells represented as blue cells, whereas purple cells indicate the CD5 …

Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner

JJ Charlton, I Chatzidakis, D Tsoukatou… - The Journal of …, 2013 - journals.aai.org
… of T EM phenotype CD8 T cells through promoting their apoptotic death and by inhibiting
conversion of T CM to T EM … Cell fate was analyzed after 42 d on the basis of CD62L and CD44 …

Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses

J Arsenio, B Kakaradov, PJ Metz, SH Kim, GW Yeo… - Nature …, 2014 - nature.com
… expression of individual CD8 + T lymphocytes throughout the … -I CD8 + T cells, which have
transgenic expression of T cell … a pair of differentiated cell fates (T CM versus T SLE ): each (…

The fate of effector CD8 T cells in vivo is controlled by the duration of antigen stimulation

X Huang, Y Yang - Immunology, 2006 - Wiley Online Library
… , whereas the fate of effector CD8 T cells was tolerance induction … Furthermore, the generation
of memory CD8 T cells … effector CD8 T cells into long-lived, functional memory CD8 T cells

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

A Singer - Current opinion in immunology, 2002 - Elsevier
… I-specific T cells into both CD4 and CD8 T-cell lineages, with … into their primary cell fate
(CD4SP T cells), whereas short-… DP thymocytes into their secondary cell fate (CD8SP T cells). …

Origin and differentiation of human memory CD8 T cells after vaccination

RS Akondy, M Fitch, S Edupuganti, S Yang, HT Kissick… - Nature, 2017 - nature.com
… We used in vivo deuterium labelling to mark CD8 T cells that … kinetics in YFV-specific CD8
T cells using mass spectrometry. … in which memory CD8 T cells originate from a subset of fate-…

Role of direct effects of IFN-γ on T cells in the regulation of CD8 T cell homeostasis

K Tewari, Y Nakayama, M Suresh - The Journal of Immunology, 2007 - journals.aai.org
T cell fate by IFN-γ is sorely incomplete. Specifically, it is unclear whether regulation of CD8
T cell homeostasis occurs by a T cell … the CD8 T cell response and generation of CD8 T cell

Generating diversity: transcriptional regulation of effector and memory CD8+ Tcell differentiation

RL Rutishauser, SM Kaech - Immunological reviews, 2010 - Wiley Online Library
… While the majority of differentiated effector cells die after pathogen clearance, a small …
memory T cells. Our understanding of how effector CD8 + T cells adopt these different cell fates

A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

BJ Fowlkes, EA Robey - The Journal of Immunology, 2002 - journals.aai.org
… as the Wnt and Notch pathways to direct T cell fate. Initial reports that Notch1 is expressed
in … to T cell tumors, prompted investigation into the role of Notch in T cell fate decisions. It is …

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

R Bosselut - Nature Reviews Immunology, 2004 - nature.com
… genes must choose either a helper CD4 + or cytotoxic CD8 + T-cell fate. Over the past two …
and differentiate into mature CD8 + T cells (if MHC class I restricted) or CD4 + T cells (if MHC …