… we propose CD8 T-cell clonal expansion within … expansion of ≥55 CD8 T-cell clones in
blood samples collected before the onset of irAEs. We propose that CD8 T-cell clonal expansion …

… the fact that clonal expansion does not alone make a T cell clone pathogenic, … of expanded
T cell clones with somatic mutations. We found that mutated T cells were mainly of cytotoxic T …

… expansion of antigen-specific CD8 T cells that occurs in response to viral infection is critically
dependent on the direct action of type I interferons (IFN-Is) on CD8 T cells. By … CD8 T cells …

… ) analysis of Vß transcripts to study these T cells in AIM patients. We show that major clonal
and/or oligoclonal populations of activated CD8 T cells account for a significant proportion of …

… the development of CD8 T cell expansions, in which a single clone of CD8 T cells, bearing
a … proportion of the total CD8 T cell pool. CD8 T cell clonal expansions are a common age-…

… As shown in this study, type I IFN can also provide the third signal for clonal expansion
and differentiation of naive CD8 T cells and does so by acting directly on the T cell. …

… Therefore, a major expansion in one Vβ population should reduce representation of T cells
… Indeed, our results show that this is true within the CD8 T cell compartment, and the fact that …

… clonal expansion of T cells by estimating the complementarity-determining region 3 size
profile among T cells … clonal expansion of the T cells by estimating the CDR3 size profile …

… We used SELECT-seq to characterize clonally expanded CD8 + memory T cells responding
to a Mycobacterium tuberculosis (Mtb) lysate. Tuberculosis (TB) is one of the top 10 causes …

… We first performed plate-seq of TCRs from CSF T cells of healthy controls (n = 5), … Clonally
expanded cells were mostly CD8 + T cells, although we also detected CD4 + T cell clones in …