Cutting edge: rapid in vivo killing by memory CD8 T cells
… the cytotoxic activity of effector and memory CD8 T cells in vivo. At the peak of the … CD8 T
cells exhibited extremely rapid killing and started to eliminate adoptively transferred target cells …
cells exhibited extremely rapid killing and started to eliminate adoptively transferred target cells …
Cutting edge: control of CD8+ T cell activation by CD4+ CD25+ immunoregulatory cells
CA Piccirillo, EM Shevach - The Journal of Immunology, 2001 - journals.aai.org
… + T cells on non-CD4 + responder cells has not been studied in detail. Here, we demonstrate
that CD4 + CD25 + T cells suppress CD8 + T cell … + CD25 + T cells on CD8 + cells are more …
that CD4 + CD25 + T cells suppress CD8 + T cell … + CD25 + T cells on CD8 + cells are more …
Cutting edge: memory CD8 T cell maturation occurs independently of CD8αα
A Chandele, SM Kaech - The Journal of Immunology, 2005 - journals.aai.org
… CD8 T cell maturation, we aimed to determine whether CD8αα controlled other aspects of
memory CD8 T cell … Through a comprehensive analysis of effector and memory CD8 T cell …
memory CD8 T cell … Through a comprehensive analysis of effector and memory CD8 T cell …
Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses
KE Foulds, LA Zenewicz, DJ Shedlock… - The Journal of …, 2002 - journals.aai.org
… stimulated CD8 T cells divided more extensively than CD4 T cells. By day 4, most CD8 T
cells had undergone more than seven rounds of division while responding CD4 T cells were …
cells had undergone more than seven rounds of division while responding CD4 T cells were …
Cutting edge: antigen-independent CD8 T cell proliferation
P Wong, EG Pamer - The Journal of Immunology, 2001 - journals.aai.org
… T lymphocytes are capable of proliferating in the absence of Ag is unknown. Herein we
demonstrate that CD8 T lymphocytes … Ag-independent expansion of CD8 T cells is driven by IL-2 …
demonstrate that CD8 T lymphocytes … Ag-independent expansion of CD8 T cells is driven by IL-2 …
Cutting edge: dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo
…, M Cannarile, I Klebba, T Brocker - The Journal of …, 2001 - journals.aai.org
The mechanism of cross-presentation enables professional APCs to induce CD8 T cell-mediated
immune responses against exogenous Ags. Through this mechanism, APCs can …
immune responses against exogenous Ags. Through this mechanism, APCs can …
The cutting edge of T cell selection
MJ Bevan - Science, 2007 - science.org
… MHC class I molecules on the surface of thymus cortical epithelial cells select the CD8 T
cell repertoire, whereas MHC class II molecules select the CD4 T cell repertoire (3). …
cell repertoire, whereas MHC class II molecules select the CD4 T cell repertoire (3). …
Cutting edge: Phenotypic characterization and differentiation of human CD8+ T cells producing IL-17
T Kondo, H Takata, F Matsuki… - The Journal of …, 2009 - journals.aai.org
… CD8 + T cells, such as naive, memory, and effector T cells, is very useful in various studies
on mouse or human T cells. In … of CD8 + T cells (10, 11). A recent study demonstrated that …
on mouse or human T cells. In … of CD8 + T cells (10, 11). A recent study demonstrated that …
Cutting edge: chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells
… CD8 T cells have increased histone acetylation compared with naive CD8 T cells; however,
those activated without CD4 T cell … acetylation in unhelped CD8 T cells and restores their …
those activated without CD4 T cell … acetylation in unhelped CD8 T cells and restores their …
Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs
… CD8 T cells within SLO expressed canonical markers of T RM , we analyzed Thy1.1 + memory
P14 CD8 T cells 8 … P14 small intestine intraepithelial lymphocytes were used as a positive …
P14 CD8 T cells 8 … P14 small intestine intraepithelial lymphocytes were used as a positive …
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