… -specific CD8 T cells directly correlates with their functional impairment and that PD-1/PD-L
blockade can restore the effector function of peripheral HCV-specific CD8 T cells. However, …

… T-cell dysfunction are not well understood. To address this question, we analysed genes
expressed in functionally impaired virus-specific CD8 T cells … of functional memory CD8 T cells. …

… for effective CD8 T cell restoration we examined the metabolic profile of exhausted CD8 T
cells in … , CD8 T cells from HIV-1 viraemic individuals are skewed toward a PD-1 hi EOMES hi …

… We then attempted to validate the T cell functional restoration effect of the immune … value
of the CD8 T cell-based phenotypic score in the context of a multispecific CD8 T cell response …

… All together, our results demonstrate a defective HCV-specific cytolytic activity at the single
CD8 T cell level, associated with an impaired de-granulation efficiency and a defective …

… specific T cell responses, which could be ineffective if T cells are … and functional characteristics
of HCV-specific CD8 T cells in … We report that a complete CD8 T cell restoration cannot be …

… of naïve cell increases that may reflect cells newly produced … cell function is demonstrable
but functional restoration is incomplete. Immunization can enhance the restoration of CD4+ cell…

… Our results show the rapid restoration of proliferative HCV-specific CD8+ T cells in the
majority of … that IFN-free therapy mediated antigen removal may restore CD8+ T cell function. …

… CD8 + T cells 19. Indeed in our study, without an increase in CD4 + T cells no improvement
of T cell function … therapy, CD4 + T cells numbers paralleled the functional T cells. However, …

… cells affect nerve regeneration. Thus, this review mainly discusses the role of T cells in the
repair of … injury and introduces studies on the treatment of nerve injury by regulating T cells. …