… contributing to CD8 + T cell failure in chronic HBV infection are not well-… NK cells and CD8
+ T cells and illustrate their contribution to viral clearance and persistence in HBV infection. …

… between HBV infected hepatocytes and HBV-specific CD8+ T cells (72). Intravital imaging
analysis revealed that HBV-specific CD8+ T cells were able to recognize HBV expressing …

… of CD8 T cells should provide the host with a greater chance to effectively control the virus
infection. This is a paradigm in HBV infection, where CD8 T cells have been shown to have a …

… HBV-specific CD8 + T cells are required for rapid viral clearance during acute HBV infection.
… acute HBV infection but can be clearly separated by CD8 depletion: a primarily noncytolytic …

… cells in response to HBV stimulation. Together, our data demonstrated that the status of
HBVspecific CD8+ T cell … associated with different clinical outcomes of chronic HBV infection. …

… exist at levels below the limit of detection in PBMCs from individuals with chronic HBV
infection, we attempted to expand CD8 + T cells specific for these epitopes by in vitro peptide …

… of a chronically infected liver is lacking. In this work, analysis of CHB patient liver parenchyma
and in vitro HBV infection models shows a nonuniform distribution of HBV CD8 + T cell …

… be playing a role in chronic HBV, we compared surface CD28 staining of CD8 T cells from
patients and controls. The percentage of CD8 T cells expressing CD28 was reduced in CHB …

… Here, we dissected the defective HBV-specific CD8 + T cell response associated with chronic
HBV infection by gene expression profiling. We found that HBV-specific CD8 + T cells from …

… + T cells on CD8 + -T-cell responses of patients with chronic and resolved hepatitis B
virus (HBV) infection. … CD4 + CD25 + T cells modulate the function and expansion of HBV-specific …